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The to and fro of tumour spread

机译:肿瘤扩散的来回

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摘要

The spread of cells from the primary site of a solid tumour to distant sites remains the major cause of disease and death associated with these cancers. For tumour cells to spread, or metastasize, they must modify their 'anchored' state and detach from their neighbouring cells; migrate through tissues into the blood and lymph systems; survive in these circulation systems; and then leave the vessels at an appropriate site to form another tumour. Many of these events are favoured by conversions between two cellular states - the epithelial and mesenchymal phenotypes. But the role of these transitions in cancer metastasis is controversial. Writing in Cancer Cell, Tsai et al. and Ocana et al. help to clarify this issue.
机译:细胞从实体瘤的原发部位扩散到远处仍然是与这些癌症有关的疾病和死亡的主要原因。为了使肿瘤细胞扩散或转移,它们必须改变其“锚定”状态并与邻近细胞分离。通过组织迁移到血液和淋巴系统;在这些循环系统中生存;然后将血管留在适当的部位以形成另一个肿瘤。这些事件中的许多事件都受到两种细胞状态(上皮和间质表型)之间的转换的支持。但是,这些转变在癌症转移中的作用是有争议的。蔡等人在《癌细胞》中写作。和Ocana等。帮助澄清这个问题。

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  • 来源
    《Nature》 |2013年第7433期|487-488|共2页
  • 作者单位

    St Vincent's Institute, Fitzroy, Victoria 3065, Australia Department of Medicine, University of Melbourne , St Vincents Hospital, Fitzroy;

    St Vincent's Institute, Fitzroy, Victoria 3065, Australia Department of Surgery, University of Melbourne, St Vincents Hospital, Fitzroy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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