Sleep deprivation alters the expression of hundreds of genes, including some whose activity normally varies depending on the time of day. Derk-Jan Dijk and his team at the University of Surrey in Guildford, UK, allowed study participants to sleep for up to 10 hours every night for one week and up to 6 hours a night another week. At the end of each week, all 26 participants were asked to stay awake for about 40 hours.
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