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Gut metagenome in European women with normal, impaired and diabetic glucose control

机译：血糖控制正常，受损和糖尿病的欧洲女性的肠道肠道基因组

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摘要

Type 2 diabetes (T2D) is a result of complex gene-environment interactions, and several risk factors have been identified, including age, family history, diet, sedentary lifestyle and obesity. Statistical models that combine known risk factors for T2D can partly identify individuals at high risk of developing the disease. However, these studies have so far indicated that human genetics contributes little to the models, whereas socio-demographic and environmental factors have greater influence. Recent evidence suggests the importance of the gut microbiota as an environmental factor, and an altered gut microbiota has been linked to metabolic diseases including obesity, diabetes and cardiovascular disease5. Here we use shotgun sequencing to characterize the faecal metagenome of 145 European women with normal, impaired or diabetic glucose control. We observe compositional and functional alterations in the metagenomes of women with T2D, and develop a mathematical model based on metagenomic profiles that identified T2D with high accuracy. We applied this model to women with impaired glucose tolerance, and show that it can identify women who have a diabetes-like metabolism. Furthermore, glucose control and medication were unlikely to have major confounding effects. We also applied our model to a recently described Chinese cohort and show that the discriminant metagenomic markers for T2D differ between the European and Chinese cohorts. Therefore, metagenomic predictive tools for T2D should be specific for the age and geographical location of the populations studied.%最新证据表明，被改变的肠道菌群与包括肥胖rn症、糖尿病和心血管疾病在内的各种代谢疾病rn相关。Fred Baeckhed及其同事对一批血糖控rn制情况正常、受损或患有糖尿病的欧洲女性的rn粪便元基因组进行了定性，并将这些发现与最rn近被描述过的一批中国女性做了对比。他们的rn分析显示了这两批女性研究对象之间在2．型糖rn尿病的判别性元基因组标记物上的差别，说明rn元基因组预测工作对于被研究人群的年龄和所rn在地域可能是有特异性的。
机译：2型糖尿病（T2D）是复杂的基因与环境相互作用的结果，已经确定了一些风险因素，包括年龄，家族病史，饮食，久坐的生活方式和肥胖症。结合了已知的T2D危险因素的统计模型可以部分识别出罹患该疾病的高风险个体。但是，到目前为止，这些研究表明，人类遗传学对模型的贡献很小，而社会人口统计学和环境因素的影响更大。最近的证据表明，肠道菌群作为环境因素的重要性，并且改变的肠道菌群与包括肥胖，糖尿病和心血管疾病在内的代谢疾病有关。在这里，我们使用shot弹枪测序来表征145名血糖正常，受损或糖尿病的欧洲女性的粪便基因组。我们观察到患有T2D的女性的基因组中的成分和功能改变，并基于宏基因组学特征开发了一种数学模型，该模型可以高精度地识别T2D。我们将此模型应用于葡萄糖耐量受损的女性，并表明它可以识别患有糖尿病样代谢的女性。此外，血糖控制和药物治疗不太可能引起重大混淆。我们还将模型应用于最近描述的中国队列，并显示欧洲和中国队列之间的T2D判别宏基因组标记有所不同。因此，用于T2D的宏基因组学预测工具应针对所研究人群的年龄和地理位置而特定。％最新证据表明，被改变的肠道菌群与包括肥胖症，糖尿病和心血管疾病体内的各种代谢弗雷德·贝克（Fred Baeckhed）和他的同事们对血糖指数控制的制止情况正常，受损或患有糖尿病的欧洲女性的粪便元基因组进行了定性，并发现这些与最rn近被描述过的一他们的rn分析显示了两个批次女性研究对象之间在2。型糖rn尿病的判别性元基因组标记物上的区别，说明rn元基因组预测工作针对被研究人群的年龄和所rn在地域可能是有一定的。

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  • 来源
    《Nature》 |2013年第7452期|99-103a2|共6页
  • 作者

    Fredlik H. Karlsson; Valentina Tremaroli; Intawat Nookaew; Goeran Bergstroem; Carl Johan Behre; Bjoern Fagerberg; Jens Nielsen; Fredrik Baeckhed;

  • 作者单位

    Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden;

    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecularand Clinical Medicine, Institute of Medicine, University of Gothenburg,SE-413 45 Gothenburg, Sweden;

    Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden;

    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecularand Clinical Medicine, Institute of Medicine, University of Gothenburg,SE-413 45 Gothenburg, Sweden;

    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecularand Clinical Medicine, Institute of Medicine, University of Gothenburg,SE-413 45 Gothenburg, Sweden;

    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecularand Clinical Medicine, Institute of Medicine, University of Gothenburg,SE-413 45 Gothenburg, Sweden;

    Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden;

    The Wallenberg Laboratory and Sahlgrenska Center for Cardiovascular and Metabolic Research, Department of Molecularand Clinical Medicine, Institute of Medicine, University of Gothenburg,SE-413 45 Gothenburg, Sweden,NovoNordisk Foundation Center for Basic Metabolic Research, Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen DK-2200, Denmark;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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