Nutrient sensing lost in cancer

SUCHITHRA MENON; BRENDAN D. MANNING

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Nutrient sensing lost in cancer

机译：营养素在癌症中丢失

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Various signals, including those stemming from nutrients such as carbohydrates and amino acids, tightly coordinate cell growth. These signals can be altered in disease states, such as obesity and cancer. Reporting in Science, Bar-Peled et aV identify a protein complex called GATOR that is crucial for linking nutrient sensing by the cell to the control of cell growth. They also find that this complex is disrupted in some cancers, hinting at a mechanism by which cancer cells disconnect their growth from normal growth-control signals.

机译：各种信号（包括源自碳水化合物和氨基酸等营养物质的信号）紧密协调细胞生长。这些信号可以在肥胖和癌症等疾病状态下改变。 Bar-Peled等人在《科学》杂志上发表的一篇文章中鉴定出一种称为GATOR的蛋白质复合物，该蛋白质复合物对于将细胞对营养的感知与细胞生长的控制联系起来至关重要。他们还发现这种复合物在某些癌症中被破坏，暗示了癌细胞将其生长与正常生长控制信号断开连接的机制。

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来源
《Nature》 |2013年第7455期|444-445|共2页
作者
SUCHITHRA MENON; BRENDAN D. MANNING;
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作者单位

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA;

Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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Nutrient sensing lost in cancer

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