Target practice

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Target practice

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Thirty-five years ago, as a fellow at the MD Anderson Cancer Center in Houston, Texas, Elihu Estey read dozens of protocols for clinical trials of drugs for acute myeloid leukaemia (AML). He was particularly drawn to their 'rationale' sections, which explain why the therapy is expected to work. "They all sounded very compelling," says Estey, now a haematologist at the University of Washington in Seattle. "But of course, very few of them worked." Since then, researchers have made significant advances in treating many types of leukaemia. However, AML-an aggressive blood cancer that causes white-blood-cell precursors called myeloid cells to proliferate uncontrollably - has remained a tough nut to crack.

机译：35年前，以利休·埃斯蒂（Elihu Estey）在德克萨斯州休斯顿的MD安德森癌症中心（MD Anderson Cancer Center）担任研究员时，阅读了数十种治疗急性髓细胞性白血病（AML）药物的临床试验方案。他特别被他们的“理性”部分吸引，这些部分解释了为什么期望这种疗法有效。现任西雅图华盛顿大学血液学家的埃斯蒂说：“它们听起来都非常引人注目。” “但是，当然，其中很少有工作。”从那时起，研究人员在治疗多种类型的白血病方面取得了重大进展。然而，AML是一种侵略性血液癌，它使称为髓样细胞的白细胞前体无法控制地增殖，但它仍然是一个难以克服的难题。

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《Nature》 |2013年第7455期|S8-S9|共2页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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Target practice

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