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Attention enhances synaptic efficacy and the signal-to-noise ratio in neural circuits

机译：注意可增强神经回路中的突触功效和信噪比

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摘要

Attention is a critical component of perception. However, the mechanisms by which attention modulates neuronal communication to guide behaviour are poorly understood. To elucidate the synaptic mechanisms of attention, we developed a sensitive assay of attentional modulation of neuronal communication. In alert monkeys performing a visual spatial attention task, we probed thalamo-cortical communication by electrically stimulating neurons in the lateral geniculate nucleus of the thalamus while simultaneously recording shock-evoked responses from monosynaptically connected neurons in primary visual cortex. We found that attention enhances neuronal communication by increasing the efficacy of presynaptic input in driving postsynaptic responses, by increasing synchronous responses among ensembles of postsynaptic neurons receiving independent input, and by decreasing redundant signals between postsynaptic neurons receiving common input. The results demonstrate that attention finely tunes neuronal communication at the synaptic level by selectively altering synaptic weights, enabling enhanced detection of salient events in the noisy sensory environment.
机译：注意是感知的重要组成部分。但是，人们对注意力调节神经元沟通以指导行为的机制了解甚少。为了阐明注意的突触机制，我们开发了一种敏感的神经元交流注意调节调制方法。在执行视觉空间注意任务的机敏猴子中，我们通过电刺激丘脑外侧膝状核中的神经元来探查丘脑与皮质的通讯，同时记录初级视觉皮层中单突触连接的神经元的电击诱发反应。我们发现，注意力通过提高突触前输入在驱动突触后反应中的功效，通过增加接收独立输入的突触后神经元的集合之间的同步响应，以及通过减少接收到公共输入的突触后神经元之间的冗余信号来增强神经元沟通。结果表明，注意力可以通过选择性地改变突触权重来微调突触水平的神经元通讯，从而能够增强在嘈杂的感觉环境中显着事件的检测。

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  • 来源
    《Nature》 |2013年第7459期|476-480|共5页
  • 作者

    Farran Briggs; George R. Mangun; W. Martin Usrey;

  • 作者单位

    CenterforNeuroscience, University of California, Davis, 1544 Newton Court, Davis, California 95618, USA,Departmentof Physiology and Neurobiology.Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, New Hampshire 03756, USA;

    Center for Mind and Brain, University of California, Davis, 267 Cousteau Place, Davis, California 95618, USA,Department of Psychology, University of California, Davis, 1 Shields Avenue, Davis, California 95616, USA,Departmentof Neurology, University of California, Davis, 4860 YStreet, Sacramento, California 95817, USA;

    CenterforNeuroscience, University of California, Davis, 1544 Newton Court, Davis, California 95618, USA,Departmentof Neurology, University of California, Davis, 4860 YStreet, Sacramento, California 95817, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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