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Biological features of novel avian influenza A (H7N9) virus

机译：新型禽流感A（H7N9）病毒的生物学特征

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摘要

Human infection associated with a novel reassortant avian influenza H7N9 virus has recently been identified in China. A total of 132 confirmed cases and 39 deaths have been reported. Most patients presented with severe pneumonia and acute respiratory distress syndrome. Although the first epidemic has subsided, the presence of a natural reservoir and the disease severity highlight the need to evaluate its risk on human public health and to understand the possible pathogenesis mechanism. Here we show that the emerging H7N9 avian influenza virus poses a potentially high risk to humans. We discover that the H7N9 virus can bind to both avian-type (a2,3-linked sialic acid) and human-type (α2,6-linked sialic acid) receptors. It can invade epithelial cells in the human lower respiratory tract and type II pneumonocytes in alveoli, and replicated efficiently in ex vivo lung and trachea explant culture and several mammalian cell lines. In acute serum samples of H7N9-infected patients, increased levels of the chemokines and cytokines IP-10, MIG, MIP-1β, MCP-1, IL-6, IL-8 and IFN-α were detected. We note that the human population is naive to the H7N9 virus, and current seasonal vaccination could not provide protection.
机译：最近在中国发现了与新型重配禽流感H7N9病毒有关的人类感染。总共报告了132例确诊病例和39例死亡。大多数患者表现出严重的肺炎和急性呼吸窘迫综合征。尽管第一个流行病已经消退，但是天然水库的存在和疾病的严重性凸显了评估其对人类公共健康的风险并了解可能的发病机理的需要。在这里，我们表明，新兴的H7N9禽流感病毒对人类构成了潜在的高风险。我们发现，H7N9病毒可以与禽类（a2,3-连接的唾液酸）和人型（α2,6-连接的唾液酸）受体结合。它可以侵袭人类下呼吸道的上皮细胞和肺泡中的II型肺细胞，并在离体肺和气管外植体培养物中以及某些哺乳动物细胞系中有效复制。在感染H7N9的患者的急性血清样本中，检测到趋化因子和细胞因子IP-10，MIG，MIP-1β，MCP-1，IL-6，IL-8和IFN-α的水平升高。我们注意到，人们对H7N9病毒还很幼稚，并且当前的季节性疫苗接种无法提供保护。

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  • 来源
    《Nature》 |2013年第7459期|500-503|共4页
  • 作者

    Jianfang Zhou; Dayan Wang; Rongbao Gao; Baihui Zhao; Jingdong Song;

  • 作者单位

    National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family PlanningCommission, Beijing 102206, China;

    National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family PlanningCommission, Beijing 102206, China;

    National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family PlanningCommission, Beijing 102206, China;

    Shanghai Municipal Disease Control and Prevention, Shanghai 200336, China;

    National Institute for Viral Disease Control and Prevention, China CDC, Key Laboratory for Medical Virology, National Health and Family PlanningCommission, Beijing 102206, China;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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