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Chromosomes captured one by one

机译:染色体被一一捕获

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摘要

Each human cell carries DNA molecules that, when combined, are more than two metres long. A fascinating problem in cell biology is, therefore, how these long molecules are organized inside the cells nucleus. This question is not just of interest from a structural perspective. Understanding chromosome folding will also provide deeper insight into genomic processes, such as the regulation of gene expression and the maintenance of genome stability. On page 59 of this issue, Nagano et al. describe a genomic approach to probing the three-dimensional arrangement of chromosomes within single cells. The results reveal large cell-to-cell variation in chromosome structure and nuclear organization, but also show that common principles of organization derived previously from cell-population studies apply to individual cells.
机译:每个人类细胞都携带DNA分子,这些分子合在一起时,长度超过两米。因此,细胞生物学中一个令人着迷的问题是这些长分子如何在细胞核内组织。从结构的角度来看,这个问题不仅令人关注。了解染色体折叠还将提供对基因组过程的更深入了解,例如基因表达的调控和基因组稳定性的维持。在此问题的第59页上,长野等人。描述了一种探测单细胞内染色体的三维排列的基因组方法。结果揭示了染色体结构和核组织中大量的细胞间差异,但也表明先前从细胞种群研究中得出的组织通用原理适用于单个细胞。

著录项

  • 来源
    《Nature》 |2013年第7469期|45-46|共2页
  • 作者

    JOB DEKKER; LEONID MIRNY;

  • 作者单位

    Program in Systems Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605-0103, USA;

    Institute for Medical Engineering and Science and in the Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
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