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Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo

机译：树突状刺突增强体内皮层神经元的刺激选择性

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摘要

Neuronal dendrites are electrically excitable: they can generate regenerative events such as dendritic spikes in response to sufficiently strong synaptic input. Although such events have been observed in many neuronal types, it is not well understood how active dendrites contribute to the tuning of neuronal output in vivo. Here we show that dendritic spikes increase the selectivity of neuronal responses to the orientation of a visual stimulus (orientation tuning). We performed direct patch-damp recordings from the dendrites of pyramidal neurons in the primary visual cortex of lightly anaesthetized and awake mice, during sensory processing. Visual stimulation triggered regenerative local dendritic spikes that were distinct from back-propagating action potentials. These events were orientation tuned and were suppressed by either hyperpolarization of membrane potential or intracellular blockade of NMDA (N-methyl-D-aspartate) receptors. Both of these manipulations also decreased the selectivity of subthreshold orientation tuning measured at the soma, thus linking dendritic regenerative events to somatic orientation tuning. Together, our results suggest that dendritic spikes that are triggered by visual input contribute to a fundamental cortical computation: enhancing orientation selectivity in the visual cortex. Thus, dendritic excitability is an essential component of behaviou-rally relevant computations in neurons.
机译：神经元树突是可电激发的：它们可响应于足够强的突触输入而产生再生事件，例如树突突刺。尽管已在许多神经元类型中观察到此类事件，但尚未充分了解活跃的树突是如何在体内调节神经元输出的。在这里，我们表明，树突状刺突增加了神经元对视觉刺激方向（定向调整）的反应的选择性。在感觉处理过程中，我们从轻度麻醉和清醒的小鼠的初级视觉皮层中的锥体神经元树突进行了直接的贴片录音。视觉刺激触发了再生树突状峰值，这不同于向后传播的动作电位。对这些事件进行了定向调整，并通过膜电位的超极化或NMDA（N-甲基-D-天冬氨酸）受体的细胞内阻滞来抑制。这两种操作还降低了在躯体处测得的亚阈值取向调节的选择性，因此将树突再生事件与体细胞取向调节联系起来。在一起，我们的结果表明，由视觉输入触发的树突状波峰有助于基本的皮层计算：增强视觉皮层中的方向选择性。因此，树突状兴奋性是神经元中行为相关计算的重要组成部分。

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  • 来源
    《Nature》 |2013年第7474期|115-120|共6页
  • 作者

    Spencer L. Smith; Ikuko T. Smith; Tiago Branco; Michael Haeusser;

  • 作者单位

    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK,Department of Cell Biology and Physiology and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA;

    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK,Department of Cell Biology and Physiology and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA;

    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK,Laboratory of Molecular Biology, Medical Research Council, Cambridge CB2 0QH, UK;

    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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