mTORCl in the Paneth cell niche couples intestinal stem-cell function to calorie intake

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• 来源
  《Nature》 |2012年第7404期|p.490-495a1|共7页
• 作者

  OEmer H. Yilmaz; Pekka Katajisto; Dudley W. Lamming; Yetis Giiltekin; Khristian E. Bauer Rowe; Shomit Sengupta; Kivanc Birsoy; Abdulmetin Dursun; V. Onur Yilmaz; Martin Selig; G. Petur Nielsen; Mari Mino Kenudson; Lawrence R. Zukerberg; Atul K. Bhan; Vikram Deshpande; David M. Sabatini;

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• 作者单位

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA,Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142: Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

  Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142: Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

  Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142: Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA,Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142: Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

  Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142: Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

  Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142: Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

  Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142: Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA;

  Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142: Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA;

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA;

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA;

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA;

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA;

  Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA;

  Whitehead Institute for Biomedical Research, Boston, Massachusetts 02142, Department of Biology, MIT, Cambridge, Massachusetts 02139, Howard Hughes Medical Institute, MIT, Cambridge, Massachusetts 02139, Broad Institute of Harvard and MIT. Seven Cambridge Center Cambridge, Massachusetts 02142, The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, Massachusetts 02139, USA;

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