首页> 外国专利> METHOD FOR PREPARING FUNCTIONAL LIVER PROGENITOR CELLS OR LIVER CELLS, OR PREPARING FUNCTIONAL SMALL-INTESTINAL EPITHELIAL PROGENITOR CELLS OR SMALL-INTESTINAL EPITHELIAL CELLS

METHOD FOR PREPARING FUNCTIONAL LIVER PROGENITOR CELLS OR LIVER CELLS, OR PREPARING FUNCTIONAL SMALL-INTESTINAL EPITHELIAL PROGENITOR CELLS OR SMALL-INTESTINAL EPITHELIAL CELLS

机译:制备功能性肝祖细胞或肝细胞,或制备功能性小肠上皮细胞或小肠上皮细胞的方法

摘要

Provided is a method for preparing functional liver (progenitor) cells or functional small-intestinal epithelial (progenitor) cells, said method comprising a step for culturing, in the presence of an antibiotic, an isolated cell population including liver (progenitor) cells or small-intestinal epithelial (progenitor) cells. Also provided is a substantially homogeneous isolated cell population including functional liver progenitor cells, wherein the expression of CYP3A4 in the functional liver progenitor cells is at least five times greater than the expression of the same in the HepaRG (registered trademark) cell line.
机译:提供了一种制备功能性肝(祖细胞)或功能性小肠上皮(祖细胞)的方法,所述方法包括在抗生素存在下培养包括肝(祖细胞)或小细胞的分离的细胞群的步骤。肠上皮(祖细胞)。还提供了包括功能性肝祖细胞的基本上均质的分离细胞群,其中CYP3A4在功能性肝祖细胞中的表达至少是其在HepaRG(注册商标)细胞系中的表达的五倍。

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