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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

机译：NIA研究显示热量限制对恒河猴健康和生存的影响

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摘要

Calorie restriction (CR), a reduction of 10-40% in intake of a nutritious diet, is often reported as the most robust non-genetic mechanism to extend lifespan and healthspan. CR is frequently used as a tool to understand mechanisms behind ageing and age-associated diseases. In addition to and independently of increasing lifespan, CR has been reported to delay or prevent the occurrence of many chronic diseases in a variety of animals. Beneficial effects of CR on outcomes such as immune function, motor coordination and resistance to sarcopenia in rhesus monkeys have recently been reported. We report here that a CR regimen implemented in young and older age rhesus monkeys at the National Institute on Aging (NIA) has not improved survival outcomes. Our findings contrast with an ongoing study at the Wisconsin National Primate Research Center (WNPRC), which reported improved survival associated with 30% CR initiated in adult rhesus monkeys (7-14years) and a preliminary report with a small number of CR monkeys. Over the years, both NIA and WNPRC have extensively documented beneficial health effects of CR in these two apparently parallel studies. The implications of the WNPRC findings were important as they extended CR findings beyond the laboratory rodent and to a long-lived primate. Our study suggests a separation between health effects, morbidity and mortality, and similar to what has been shown in rodents, study design, husbandry and diet composition may strongly affect the life-prolonging effect of CR in a long-lived nonhuman primate.
机译：热量限制（CR），一种营养饮食的摄入量减少了10-40％，通常被报告为延长寿命和健康的最健壮的非遗传机制。 CR通常被用作了解衰老和与年龄相关疾病背后机制的工具。除了且不依赖于延长寿命，据报道CR可延缓或预防多种动物中许多慢性疾病的发生。最近已经报道了CR对恒河猴免疫功能，运动协调和对少肌症抵抗力的有益作用。我们在这里报告说，在美国国家老龄研究所（NIA）的年轻和较老恒河猴中实施的CR疗法并没有改善生存率。我们的发现与威斯康星州国家灵长类动物研究中心（WNPRC）正在进行的研究形成了鲜明对比，该研究报告了成年猕猴（7-14岁）中启动30％CR所带来的生存改善，以及少量CR猴的初步报告。多年来，NIA和WNPRC都在这两个表面上平行的研究中广泛记录了CR对健康的有益影响。 WNPRC研究结果的意义非常重要，因为它们将CR研究结果扩展到了实验室啮齿动物之外，并延伸到了长寿的灵长类动物。我们的研究表明，对健康的影响，发病率和死亡率之间存在差异，与啮齿动物所显示的相似，研究设计，饲养和饮食组成可能会强烈影响长寿的非人类灵长类动物的CR寿命。

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  • 来源
    《Nature》 |2012年第7415期|p.318-321|共4页
  • 作者

    Julie A. Mattison; George S. Roth; T. Mark Beasley; Edward M. Tilmont; April M. Handy; Richard L. Herbert; Dan L. Longo; David B. Allison; Jennifer E. Young; Mark Bryant; Dennis Barnard; Walter F. Ward; Wenbo Qi; Donald K. Ingram; Rafael de Cabo;

  • 作者单位

    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, 16701 Elmer School Road Building 103, Dickerson, Maryland 20842, USA;

    GeroScience, 1124 Ridge Road Pylesville, Maryland 21132, USA;

    Department of Biostatistics.Ryals Public Health Bldg343C University of Alabama at Birmingham, 1530 3rd Avenue S.Birmingham, Alabama 35294, USA;

    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, 16701 Elmer School Road Building 103, Dickerson, Maryland 20842, USA;

    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, 16701 Elmer School Road Building 103, Dickerson, Maryland 20842, USA,SoBran, Inc., 4000 Blackburn Lane, Suite 100, Burtonsville, Maryland 20866, USA;

    National Institute of Allergy and Infectious Disease, NIH Animal Center, 16701 Elmer School Road, Building 102, Dickerson, Maryland 20842, USA;

    Laboratory of Molecular Biology and Immunology, National Institute on Aging, NIH, 251 Bayview Boulevard Room 08C228, Baltimore, Maryland 21224, USA;

    Office of Energetics, University of Alabama at Birmingham, 1665 University Boulevard, RPH 140J Birmingham, Alabama 35294, USA;

    Laboratory of Experimental Gerontology, National Institute on Aging, NIH Animal Center, 16701 Elmer School Road Building 103, Dickerson, Maryland 20842, USA;

    Office of the Director, Diagnostic and Research Services Branch, NIH, Bldg 28A, Room 114,28 Service Road West, Bethesda, Maryland 20814, USA;

    Office of the Director, Diagnostic and Research Services Branch, NIH, Building 14A, Room 119A, 14 Service Road West, Bethesda, Maryland 20814, USA;

    Department of Physiology/Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA;

    Department of Cellular and Structural Biology/ Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA;

    Nutritional Neuroscienceand Aging Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA;

    Laboratory of Experimental Gerontology, National Institute on Aging, NIH, 251 Bayview Boulevard Suite 100, Baltimore, Maryland 21224, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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