• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs
【24h】

Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs

机译：藻类基因组揭示了进化镶嵌和核型的命运

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

这篇论文介绍了两种具有很大基因和细胞复杂rn性的真核微生物(Guillardia和Bigelowiella)的核rn基因组的序列。这些藻类是通过吞食真核藻类rn以内共生方式获得光合作用过程中的过渡形rn式，它们有四个基因组：线粒体和质体(叶绿rn体)基因组、一个来源于宿主的核基因组和一rn个来源于内共生的微型化的“类核体”基因rn组。分析显示，它们具有对一种单细胞生物来rn说的前所未有的另类剪接方式和广泛的基因和rn生化“镶嵌性”。虽然从线粒体到核的基因转rn移在两种生物中都在继续，但从质体到核及从rn“类核体”到核的转移已经停止，这可以解释rn为什么“类核体”持久存在。%Cryptophyte and chlorarachniophyte algae are transitional forms in the widespread secondary endosymbiotic acquisition of photosynthesis by engulfment of eukaryotic algae. Unlike most secondary plastid-bearing algae, miniaturized versions of the endosymbiont nuclei (nucleomorphs) persist in cryptophytes and chlorarachniophytes. To determine why, and to address other fundamental questions about eukaryote-eukaryote endosymbiosis, we sequenced the nuclear genomes of the cryptophyte Guillardia theta and the chlorarachniophyte Bigelowiella natans. Both genomes have >21,000 protein genes and are intron rich, and B. natans exhibits unprecedented alternative splicing for a single-celled organism. Phylogenomic analyses and subcellular targeting predictions reveal extensive genetic and biochemical mosaicism, with both host- and endosymbiont-derived genes servicing the mitochondrion, the host cell cytosol, the plastid and the remnant endosymbiont cytosol of both algae. Mitochondrion-to-nucleus gene transfer still occurs in both organisms but plastid-to-nucleus and nucleomorph-to-nucleus transfers do not, which explains why a small residue of essential genes remains locked in each nucleomorph.
机译：这篇论文介绍了两种具有很大基因和细胞复杂rn性的真核微生物(Guillardia和Bigelowiella)的核rn基因组的序列。这些藻类是通过吞食真核藻类rn以内共生方式获得光合作用过程中的过渡形rn式，它们有四个基因组：线粒体和质体(叶绿rn体)基因组、一个来源于宿主的核基因组和一rn个来源于内共生的微型化的“类核体”基因rn组。分析显示，它们具有对一种单细胞生物来rn说的前所未有的另类剪接方式和广泛的基因和rn生化“镶嵌性”。虽然从线粒体到核的基因转rn移在两种生物中都在继续，但从质体到核及从rn“类核体”到核的转移已经停止，这可以解释rn为什么“类核体”持久存在。%Cryptophyte and chlorarachniophyte algae are transitional forms in the widespread secondary endosymbiotic acquisition of photosynthesis by engulfment of eukaryotic algae. Unlike most secondary plastid-bearing algae, miniaturized versions of the endosymbiont nuclei (nucleomorphs) persist in cryptophytes and chlorarachniophytes. To determine why, and to address other fundamental questions about eukaryote-eukaryote endosymbiosis, we sequenced the nuclear genomes of the cryptophyte Guillardia theta and the chlorarachniophyte Bigelowiella natans. Both genomes have >21,000 protein genes and are intron rich, and B. natans exhibits unprecedented alternative splicing for a single-celled organism. Phylogenomic analyses and subcellular targeting predictions reveal extensive genetic and biochemical mosaicism, with both host- and endosymbiont-derived genes servicing the mitochondrion, the host cell cytosol, the plastid and the remnant endosymbiont cytosol of both algae. Mitochondrion-to-nucleus gene transfer still occurs in both organisms but plastid-to-nucleus and nucleomorph-to-nucleus transfers do not, which explains why a small residue of essential genes remains locked in each nucleomorph.

著录项

  • 来源
    《Nature》 |2012年第7427期|59-65a2|共8页
  • 作者

    Bruce A. Curtis; Goro Tanifuji; Fabien Burki; Ansgar Gruber; Manuel Irimia; et al;

  • 作者单位

    Department of Biochemistry and Molecular Biology, Dalbousie University, Halifax, Nova Scotia B3H4R2, Canada Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University,Halifax, Nova Scotia B3H 4R2, Canada Integrated Microbial Biodiversity Program, Canadian Institute for Advanced Research, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada;

    Department of Biochemistry and Molecular Biology, Dalbousie University, Halifax, Nova Scotia B3H4R2, Canada Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University,Halifax, Nova Scotia B3H 4R2, Canada Integrated Microbial Biodiversity Program, Canadian Institute for Advanced Research, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada;

    Integrated Microbial Biodiversity Program, Canadian Institute for Advanced Research, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada;

    Fachbereich Biologie, Universitaet Konstanz, 78457 Konstanz, Germany;

    Department of Medical Research and Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号