Initial impact of the sequencing of the human genome

Eric S. Lander

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Initial impact of the sequencing of the human genome

机译：人类基因组测序的初步影响

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摘要

The sequence of the human genome has dramatically accelerated biomedical research. Here I explore its impact, in the decade since its publication, on our understanding of the biological functions encoded in the genome, on the biological basis of inherited diseases and cancer, and on the evolution and history of the human species. I also discuss the road ahead in fulfilling the promise of genomics for medicine.

机译：人类基因组的序列极大地加速了生物医学研究。在这里，我探讨了它对自基因组编码以来的生物学功能的理解，对遗传疾病和癌症的生物学基础以及对人类物种的进化和历史的影响。我还将讨论实现医学基因组学前景的道路。

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来源
《Nature》 |2011年第7333期|p.187-197|共11页
作者
Eric S. Lander;
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作者单位

Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
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1. An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing [J] . Elliott H. Margulies, Jade P. Vinson, NISC Comparative Sequencing Program, Proceedings of the National Academy of Sciences of the United States of America . 2005,第13期

机译：通过低冗余比较测序系统鉴定人类基因组功能元件的初步策略
2. Demographic inference from whole-genome and RAD sequencing data suggests alternating human impacts on goose populations since the last ice age [J] . Pujolar J. M., Dalen L., Hansen M. M., Molecular ecology . 2017,第22期

机译：来自全基因组和RAD测序数据的人口统计推断表明自上次冰河时代以来的鹅群对鹅口的交替
3. Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells [J] . Yang Luhan, Grishin Dennis, Wang Gang, Nature Communications . 2014,第Nova期

机译：靶向和全基因组测序揭示单核苷酸变异影响人干细胞中Cas9的特异性
4. Megabase sequencing of human genome by ordered-shotgun-sequencing (OSS) strategy [C] . Ellson Y. Chen, Applied Biosystems Div. of Perkin-Elmer, Foster City, Ultrasensitive Biochemical Diagnostics II . 1997

机译：通过有序shot弹枪测序（OSS）策略对人类基因组进行Megabase测序
5. The Impact of Human Genome Project, International HapMap Project and Next Generation Sequencing to the R&D process of Pharmaceutical Industry [D] . Wong, Kwun Ngok 2013

机译：人类基因组计划，国际HapMap项目和下一代测序对制药业研发过程的影响
6. An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing [O] . Elliott H. Margulies, Jade P. Vinson, Webb Miller, 2005

机译：通过低冗余比较测序系统鉴定人类基因组功能元件的初步策略
7. Initial impact of the sequencing of the human genome [O] . Eric S. Lander 2011

机译：人类基因组测序的初始影响

Initial impact of the sequencing of the human genome

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