The to and fro of RNA polymerase

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The to and fro of RNA polymerase

机译：RNA聚合酶的来回

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Rna polymerase Ⅱ (RNA pol Ⅱ) moves forwards along the DNA strand during gene transcription, synthesizing messenger RNA as it goes. It can also move backwards and stall - a useful property for regulatory purposes or if it hits an obstacle such as a nucleosome. This arrested state is reactivated by transcription factor IIS (TFIIS). Now, the crystal structure of a backtracked yeast RNA pol II complex containing observable backtracked RNA has been determined at 3.3 A resolution, as well as the structure of a backtracked complex containing TFIIS.

机译：Rna聚合酶Ⅱ（RNA polⅡ）在基因转录过程中沿着DNA链向前移动，从而合成信使RNA。它也可以向后移动并失速-这是一种有用的属性，可用于监管或碰到核小体等障碍物。转录因子IIS（TFIIS）重新激活了该停止状态。现在，已经以3.3 A的分辨率确定了包含可观察到的回溯RNA的回溯酵母RNA pol II复合物的晶体结构，以及包含TFIIS的回溯复合物的结构。

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《Nature》 |2011年第7335期|p.467|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases [J] . Lakshminarayan M Iyer, Eugene V Koonin, L Aravind BMC Structural Biology . 2003,第1期

机译：DNA依赖的RNA聚合酶和真核RNA依赖的RNA聚合酶的催化亚基之间的进化联系和RNA聚合酶的起源
2. N4 RNA Polymerase II, a Heterodimeric RNA Polymerase with Homology to the Single-Subunit Family of RNA Polymerases [J] . S. H. Willis, K. M. Kazmierczak, R. H. Carter, Journal of bacteriology . 2002,第18期

机译：N4 RNA聚合酶II，具有与RNA聚合酶单亚基家族同源的异二聚体RNA聚合酶
3. Bacterial RNA polymerase subunit ω and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly [J] . Leonid Minakhin, Sechal Bhagat, Adrian Brunning Proceedings of the National Academy of Sciences of the United States of America . 2001,第3期

机译：细菌RNA聚合酶亚基ω和真核RNA聚合酶RPB6是序列，结构和功能同源物，可促进RNA聚合酶装配
4. Abnormal rapid non-linear RNA production induced by T7 RNA polymerase in the absence of an exogenous DNA template [C] . Y. Kakimoto, A. Fujinuma, S. Fujita, Irago Conference . 2015

机译：在没有外源DNA模板的情况下，T7 RNA聚合酶诱导的异常快速非线性RNA产生
5. Functional characterization of FRO4 and FRO5: Two members of the ferric chelate reductase family of Arabidopsis. [D] . Wilson, Grandon Thomas. 2014

机译：FRO4和FRO5的功能表征：拟南芥铁螯合还原酶家族的两个成员。
6. Transcriptome Sequencing Identifies SPL7-Regulated Copper Acquisition Genes FRO4/FRO5 and the Copper Dependence of Iron Homeostasis in Arabidopsis [O] . María Bernal, David Casero, Vasantika Singh, 2012

机译：转录组测序确定拟南芥中SPL7调控的铜收购基因FRO4 / FRO5和铁稳态的铜依赖性。
7. Evolutionary connection between the catalytic subunits of DNA-dependent RNA polymerases and eukaryotic RNA-dependent RNA polymerases and the origin of RNA polymerases [O] . Iyer Lakshminarayan M, Koonin Eugene V, Aravind L 2003

机译：DNA依赖的RNA聚合酶和真核RNA依赖的RNA聚合酶的催化亚基之间的进化联系和RNA聚合酶的起源

The to and fro of RNA polymerase

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