Caspases and neurotoxicity

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Caspases and neurotoxicity

机译：胱天蛋白酶和神经毒性

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Brain inflammation is a typical feature of neurodegenerative diseases and acute forms of brain injury. Microglia are thought to play a part in the pathogenesis of such disorders by secreting neurotoxic cytokines. Experiments in cell and animal models of inflammation show that microglia activation requires the orderly activation of caspase-8 and caspase-3/7 - well known as agents of cell death. Inhibition of the caspase cascade prevents activation of microglia and prevents neurotoxicity.

机译：脑部炎症是神经退行性疾病和急性形式脑损伤的典型特征。小胶质细胞通过分泌神经毒性细胞因子被认为在此类疾病的发病机理中起作用。在炎症的细胞和动物模型中进行的实验表明，小胶质细胞的激活需要caspase-8和caspase-3 / 7的有序激活，这是众所周知的细胞死亡试剂。抑制半胱天冬酶级联反应可防止小胶质细胞活化并防止神经毒性。

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《Nature》 |2011年第7337期|p.167|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. beta-amyloid induces caspase-dependent early neurotoxic change in PC12 cells: correlation with H2O2 neurotoxicity. [J] . Saito T, Kijima H, Kiuchi Y, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2001,第1期

机译：β淀粉样蛋白诱导PC12细胞中caspase依赖的早期神经毒性变化：与H2O2神经毒性相关。
2. Zinc down regulates Apaf-1-dependent Bax/Bcl-2 mediated caspases activation during aluminium induced neurotoxicity [J] . Singla Neha, Dhawan D. K. BioMetals: An International Journal on the Role of Metal Ions in Biology, Biochemistry and Medicine . 2015,第1期

机译：锌在铝诱导的神经毒性中下调Apaf-1依赖性Bax / Bcl-2介导的胱天蛋白酶激活
3. Cocaine Induces a Differential Dose-Dependent Alteration in the Expression Profile of Immediate Early Genes, Transcription Factors, and Caspases in PC12 Cells: A Possible Mechanism of Neurotoxic Damage in Cocaine Addiction [J] . SYED Z. IMAM, HELEN M. DUHART, JOHN T. SKINNER, Annals of the New York Academy of Sciences . 2005,第AUG期

机译：可卡因诱导PC12细胞中早期早期基因，转录因子和胱天冬酶表达谱的剂量依赖性变化：可卡因成瘾的神经毒性损害的可能机制
4. Pituitary adenylate cyclase-activating polypeptide inhibited the beta-amyloid-induced neurotoxicity and activation of caspase-3 [C] . Kosuke Endo, Satomi Onoue, Keiichi Ohshima, European Peptide Symposium . 2002

机译：垂体腺苷酸环酶活化多肽抑制β-淀粉样蛋白诱导的神经毒性和Caspase-3的活化
5. Caspases and caspase regulators in Lepidoptera and Diptera. [D] . Bryant, William Barton. 2009

机译：鳞翅目和双翅目中的胱天蛋白酶和胱天蛋白酶调节剂。
6. Edaravone protects rat astrocytes from oxidative or neurotoxic inflammatory insults by restoring Akt/Bcl-2/Caspase-3 signaling axis [O] . Zhe Guo, Huan-Tong Wu, Xi-Xi Li, 2020

机译：埃及龙酮通过恢复AKT / BCL-2 / Caspase-3信号轴来保护大鼠星形胶质细胞免受氧化或神经毒性炎症损伤
7. THE EXPRESSION OF CASPASE-3 IN THE MECHANISMS OF CAPSAICIN-INDUCED NEUROTOXICITY CALBINDIN-CONTAINING INTERNEURONS OF THE SPINAL CORD OF THE MOUSE [O] . Valentina Porseva, Andrey Emanuilov, Dmitriy Omelchenko, 2019

机译：Caspase-3在辣椒素诱导的小鼠脊髓含神经毒性Calbindin的细胞间的机制中的表达
8. Screening for Small Molecules That Disrupt IAP-Caspases Binding to Activate Caspases and Induce Apoptosis in Breast Cancers [R] . Sun, Y. 2005

机译：筛选破坏Iap-半胱天冬酶结合激活半胱天冬酶并诱导乳腺癌细胞凋亡的小分子

Caspases and neurotoxicity

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