Metal-catalysed cross-coupling reactions are reactions that join two molecularfragments usinga metal as catalyst The 2010 Nobel Prize in Chemistry was awarded to pioneers of palladium-catalysed carbon-carbon cross-coupling reactions first disclosed over 40 years ago96. Since then, cross-coupling reactions have become a staple of modern organic synthesis and have been developed for virtually every element in the first and second row of the p-block of the periodic table.
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