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Neural crest regulates myogenesis through the transient activation of NOTCH

机译：神经rest通过Notch的瞬时激活来调节肌发生

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摘要

How dynamic signalling and extensive tissue rearrangements interact to generate complex patterns and shapes during embryo-genesis is poorly understood. Here we characterize the signalling events taking place during early morphogenesis of chick skeletal muscles. We show that muscle progenitors present in somites require the transient activation of NOTCH signalling to undergo terminal differentiation. The NOTCH ligand Deltal is expressed in a mosaic pattern in neural crest cells that migrate past the somites. Gain and loss of Deltal function in neural crest modifies NOTCH signalling in somites, which results in delayed or premature myogenesis. Our results indicate that the neural crest regulates early muscle formation by a unique mechanism that relies on the migration of Deltal-expressing neural crest cells to trigger the transient activation of NOTCH signalling in selected muscle progenitors. This dynamic signalling guarantees a balanced and progressive differentiation of the muscle progenitor pool.
机译：人们对动态信号传递和广泛的组织重排如何相互作用以在胚胎发生过程中产生复杂的图案和形状了解甚少。在这里，我们表征了雏鸡骨骼肌早期形态发生过程中发生的信号传递事件。我们表明，存在于腹节中的肌肉祖细胞需要短暂激活NOTCH信号传导以进行终末分化。 NOTCH配体Deltal在迁移通过体节的神经c细胞中以镶嵌方式表达。神经c中德尔塔尔功能的获得和丧失会改变体节中的NOTCH信号传导，从而导致延迟或过早的肌发生。我们的结果表明，神经c通过独特的机制调节早期肌肉的形成，该机制依赖于表达Deltal的神经rest细胞的迁移，从而触发选定肌肉祖细胞中NOTCH信号的瞬时激活。这种动态信号传递保证了肌肉祖细胞的平衡和进行性分化。

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  • 来源
    《Nature》 |2011年第7348期|p.532-535|共4页
  • 作者

    Anne C. Rios; Olivier Serralbo; David Salgado; Christophe Marcelle;

  • 作者单位

    EMBL Australia, Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia;

    EMBL Australia, Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia;

    EMBL Australia, Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia;

    EMBL Australia, Australian Regenerative Medicine Institute (ARMI), Monash University, Building 75, Clayton, Victoria 3800, Australia;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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