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Magnesium in a signalling role

机译：镁在信号传导中的作用

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摘要

Humans fend off offending agents such as pathogens and tumour cells using their immune system. When immune function is diminished as a result of immunodeficiencies, individuals become more susceptible to infections and, in some cases, to cancer. Immunodeficiencies can result from defects in any component of the immune system, including T cells and B cells. These disorders can be hereditary (primary immunodeficiencies) or acquired - for example, through infection with viruses such as HIV1. Although primary immunodeficiencies are rare, their study has frequently led to identification of new, and at times unsuspected, regulators of the immune system. On page 471 of this issue, Li and colleagues2 describe one such regulator, the magnesium-ion transporter MAGT1, mutations in which result in a hereditary human immunodeficiency.
机译：人类利用自己的免疫系统抵御病原体和肿瘤细胞等有害物质。当由于免疫缺陷导致免疫功能下降时，个体变得更容易受到感染，在某些情况下更易患癌症。免疫缺陷可能是由于免疫系统任何组件（包括T细胞和B细胞）的缺陷所致。这些疾病可以是遗传性的（原发性免疫缺陷），也可以是后天性的-例如，通过感染诸如HIV1的病毒。尽管原发性免疫缺陷很少见，但他们的研究经常导致鉴定新的，有时甚至不受怀疑的免疫系统调节剂。 Li及其同事在第471页上描述了一种这样的调节子，即镁离子转运蛋白MAGT1，这种突变导致人类的遗传性免疫缺陷。

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  • 来源
    《Nature》 |2011年第7357期|p.462-463|共2页
  • 作者

    NING WU; ANDRE VEILLETTE;

  • 作者单位

    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, H2W1R7 Canada. Andre Veillette is also in the Department of Medicine, University of Montreal, and in the Department of Medicine, McGill University, Montreal;

    Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montreal, Quebec, H2W1R7 Canada. Andre Veillette is also in the Department of Medicine, University of Montreal, and in the Department of Medicine, McGill University, Montreal;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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