Product Focus: Drug Screening / Discovery

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Product Focus: Drug Screening / Discovery

机译：产品重点：药物筛选/发现

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the mechanism of cell death. The ratio of living cells to dead cells is independent of cell number, making this measure more accurate when comparing samples from well-to-well, plate-to-plate, and day-to-day. The assay is flexible and easily automated with component volumes that can be scaled to meet throughput needs, from 96- to 1536-well plate formats.rnSimilarly, Active Motif has recently released a new product for the screening of histone modifications. The new MODified™ HistonernPeptide array allows you to obtain more complete antibody cross-reactivity or enzyme and protein binding interaction data by evaluating histone modifications in combination instead of studying individual modifications. The MODified Histone Peptide Array is a novel research tool that screens 59 acetylation, methylation, phos-phorylation and citrullination modifications on the N-terminal tails of histones H2A, H2B, H3 and H4. Each 19mer peptide contains between one to four different modifications, enabling the study not only of individual sites, but also the effects of neighboring modifications on site recognition and binding.

机译：细胞死亡的机制。活细胞与死细胞的比率与细胞数无关，因此在比较孔与孔，板对板和日常样品时，此测量更加准确。该测定法灵活且易于自动化，其组分体积可缩放以满足96到1536孔板规格的通量需求。类似地，Active Motif最近也发布了一种用于筛选组蛋白修饰的新产品。新型MODified™HistonernPeptide阵列可让您通过组合评估组蛋白修饰而不是研究单个修饰来获得更完整的抗体交叉反应性或酶与蛋白质结合相互作用数据。修饰的组蛋白肽阵列是一种新颖的研究工具，可筛选组蛋白H2A，H2B，H3和H4的N末端尾巴上的59个乙酰化，甲基化，磷酸化和瓜氨酸化修饰。每个19mer肽都包含1-4个不同的修饰，不仅可以研究单个位点，还可以研究邻近修饰对位点识别和结合的影响。

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《Nature》 |2011年第7357期|p.A2|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Diversity screening versus focussed screening in drug discovery. [J] . Valler MJ, Green D Drug discovery today . 2000,第7期

机译：药物发现中的多样性筛选与重点筛选。
2. Diversity screening versus focussed screening in drug discovery. [J] . Valler MJ, Green D Drug discovery today . 2000,第7期

机译：药物发现中的多样性筛选与重点筛选。
3. High-Content Screening Data Management for Drug Discovery in a Small- to Medium-Size Laboratory: Results of a Collaborative Pilot Study Focused on User Expectations as Indicators of Effectiveness [J] . Cynthia A. Berlinicke, Christopher F. Ackermann, Steve H. Chen, JALA: Journal of the Association for Laboratory Automation . 2012,第4期

机译：中小型实验室中用于药物发现的高筛选数据管理：一项以用户期望为重点的协同试验研究结果
4. Data Mining: A Unifying Approach for Drug Discovery Integrating genomics, combinatorial chemistry, high throughput screening, and DNA microarrays for drug discovery [C] . Leming Shi Biochip technologies . 2000

机译：数据挖掘：药物发现的统一方法整合基因组学，组合化学，高通量筛选和DNA微阵列进行药物发现
5. Informatics in drug discovery: Identifying transcription factor targets and structure-based drug screening. [D] . Kamalakaran, Sitharthan. 2004

机译：药物发现中的信息学：确定转录因子靶标和基于结构的药物筛选。
6. Induced Pluripotent Stem Cells: From Product-Focused Disease Modeling to Process-Focused Disease Discovery [O] . Katherine A. Campbell, Andre Terzic, Timothy J. Nelson -1

机译：诱导多能干细胞：从以产品为中心的疾病建模到以过程为中心的疾病发现
7. High-content screening data management for drug discovery in a small- to medium-size laboratory: Results of a collaborative pilot study focused on user expectations as indicators of effectiveness [O] . Berlinicke, C.A., Ackermann, C.F., Chen, S.H., 2012

机译：针对中小型实验室药物发现的高内容筛查数据管理：协作试点研究的结果侧重于用户期望作为有效性的指标

Product Focus: Drug Screening / Discovery

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