• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization
【24h】

Oxygen sensing in plants is mediated by an N-end rule pathway for protein destabilization

机译：植物中的氧气感应是通过N端规则途径来破坏蛋白质的稳定性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The majority of eukaryotic organisms rely on molecular oxygen for respiratory energy production1. When the supply of oxygen is compromised, a variety of acclimation responses are activated to reduce the detrimental effects of energy depletion2"4. Various oxygen-sensing mechanisms have been described that are thought to trigger these responses5"9, but they each seem to be kingdom specific and no sensing mechanism has been identified in plants until now. Here we show that one branch of the ubiquitin-dependent N-end rule pathway for protein degradation, which is active in both mammals and plants10'11, functions as an oxygen-sensing mechanism in Arabidopsis thaliana. We identified a conserved amino-terminal amino acid sequence of the ethylene response factor (ERF)-transcription factor RAP2.12 to be dedicated to an oxygen-dependent sequence of post-translational modifications, which ultimately lead to degradation of RAP2.12 under aerobic conditions. When the oxygen concentration is low-as during flooding-RAP2.12 is released from the plasma membrane and accumulates in the nucleus to activate gene expression for hypoxia acclimation. Our discovery of an oxygen-sensing mechanism opens up new possibilities for improving flooding tolerance in crops.
机译：大多数真核生物依靠分子氧来产生呼吸能量1。当氧气供应受到损害时，会激活各种适应反应以减少能量消耗的不利影响2“ 4。已描述了各种氧气感应机制来触发这些反应5” 9，但它们似乎都是直到现在，还没有发现特定于植物王国的感官机制。在这里，我们显示了遍在蛋白依赖性N端蛋白质降解的规则途径的一个分支，该分支在哺乳动物和植物10'11中均活跃，在拟南芥中起着氧敏感机制的作用。我们确定了乙烯反应因子（ERF）转录因子RAP2.12的保守的氨基末端氨基酸序列，专门用于依赖氧的翻译后修饰序列，最终导致有氧条件下RAP2.12的降解条件。当氧浓度低时（例如在洪水期间），RAP2.12从质膜释放并积累在核中，以激活基因表达以适应缺氧。我们对氧气感应机制的发现为提高农作物的耐洪能力开辟了新的可能性。

著录项

  • 来源
    《Nature》 |2011年第7373期|p.419-422|共4页
  • 作者

    Francesco Licausi; Monika Kosmacz; Daan A. Weits; Beatrice Giuntoli; Federico M. Giorgi; Laurentius A. C. J. Voesenek; Pierdomenico Perata; Joost T. van Dongen;

  • 作者单位

    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1,14476, Potsdam-Golm, Germany,Plantl_ab, Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martin delta Liberta 33,56127 Pisa, Italy;

    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1,14476, Potsdam-Golm, Germany;

    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1,14476, Potsdam-Golm, Germany;

    Plantl_ab, Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martin delta Liberta 33,56127 Pisa, Italy;

    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1,14476, Potsdam-Golm, Germany;

    Plant Ecophysiology, Institute of Environmental Biology, Utrecht University, Padualaan 8,3584 CH Utrecht, the Netherlands,Centre for BiosystemsGenomics,6708PBWageningen,the Netherlands;

    Plantl_ab, Institute of Life Sciences, Scuola Superiore Sant'Anna, Piazza Martin delta Liberta 33,56127 Pisa, Italy;

    Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1,14476, Potsdam-Golm, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号