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Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

机译:秀丽隐杆线虫的长寿跨代表观遗传

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摘要

Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants.%人们知道,简单性状(如植物花的特点和果蝇的眼睛颜色)可以隔代遗传。这篇文章介绍了一个复杂性状的隔代后生(外成)遗传:线虫后天获得的长寿命。对父辈ASH-2复合物的H3K4mle3染色质修饰因子的操控,能够延长rn随后三代的寿命。这些发现表明,父辈中的染色质改变也许并不会在不同世代之间完全重设(复位),同时它们也为寿命的后生(外成)遗传提供了第一个证据。
机译:染色质修饰剂调节着几种生物的寿命,这引发了一个问题,即下一代中的染色质状态变化是否可以在下一代中不完全重新编程,从而影响后代的寿命。由ASH-2,WDR-5和组蛋白甲基转移酶SET-2组成的组蛋白H3赖氨酸4三甲基化(H3K4me3)复合物可调节秀丽隐杆线虫的寿命。在这里,我们证明了H3K4me3染色质修饰剂ASH-2,WDR-5或SET-2在亲代中的缺陷将后代的寿命延长到第三代。 ASH-2复合物成员对寿命延长的跨代继承取决于H3K4me3脱甲基酶RBR-2,并且在后代中需要有功能的种系。 H3K4me3甲基化复合体的寿命跨代遗传是特定的,并且与基因表达的表观遗传学变化有关。因此,仅在父母中操作特定的染色质修饰剂可以诱导后代长寿的表观遗传记忆。%有人知道,简单性状(如植物花的特点和果蝇的眼睛颜色)可以隔代遗传。对父辈ASH-2复合物的H3K4mle3染色质修饰因子的作用,能够延长由三代的寿命。这些发现表明,父辈中的染色质改变也许并不会在不同世代之间完全重设(重置),同时它们也为寿命的后生(外成)遗传提供了第一个证据。

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  • 来源
    《Nature》 |2011年第7373期|p.365-371|共7页
  • 作者单位

    Departmentof Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA,Cell Biology Department, Harvard Medical School and Division of Newborn Medicine, Children's Hospital,300 Longwood Avenue, Boston, Massachusetts 02115, USA;

    Departmentof Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA;

    Departmentof Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA;

    Departmentof Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA;

    Departmentof Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA;

    Departmentof Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA;

    Departmentof Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA;

    Cell Biology Department, Harvard Medical School and Division of Newborn Medicine, Children's Hospital,300 Longwood Avenue, Boston, Massachusetts 02115, USA;

    Departmentof Genetics, Stanford University, 300 Pasteur Drive, Stanford, California 94305, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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