• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Neuronal filtering of multiplexed odour representations
【24h】

Neuronal filtering of multiplexed odour representations

机译：神经元过滤的多重气味表示

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

斑马鱼和其他物种嗅球中的神经元通过复杂的rn放电对气味做出反应,其放电含有振荡成分和rn非振荡成分,但这些不同成分在功能上的重要rn性尚不清楚.Rainer Friedrich及其同事利用光rn学遗传模拟,对端脑背侧(Dp,相当于斑马鱼rn的嗅觉皮层)的后部区域(postenor zorle)中的rn振荡嗅球活动的下游读出数据直接进行了研rn究.Dp神经元在很大程度上对同步振荡活动rn是不敏感的,但会对稳定态的活动做出反应.rn这些发现用Dp神经元的像过滤器一样的"低rn通"(low-pass)生物物理性质有可能得到解rn释,同时也说明了过滤作用何以能提取出神经rn元编码的个别成分.%Neuronal activity patterns contain information in their temporal structure, indicating that information transfer between neurons may be optimized by temporal filtering. In the zebrafish olfactory bulb, subsets of output neurons (mitral cells) engage in synchronized oscillations during odour responses, but information about odour identity is contained mostly in non-oscillatory firing rate patterns. Using optogenetic manipulations and odour stimulation, we found that firing rate responses of neurons in the posterior zone of the dorsal telencephalon (Dp), a target area homologous to olfactory cortex, were largely insensitive to oscillatory synchrony of mitral cells because passive membrane properties and synaptic currents act as low-pass filters. Nevertheless, synchrony influenced spike timing. Moreover, Dp neurons responded primarily during the decorrelated steady state of mitral cell activity patterns. Temporal filtering therefore tunes Dp neurons to components of mitral cell activity patterns that are particularly informative about precise odour identity. These results demonstrate how temporal filtering can extract specific information from multiplexed neuronal codes.
机译：斑马鱼和其他物种嗅球中的神经元通过复杂的rn放电对气味做出反应,其放电含有振荡成分和rn非振荡成分,但这些不同成分在功能上的重要rn性尚不清楚.Rainer Friedrich及其同事利用光rn学遗传模拟,对端脑背侧(Dp,相当于斑马鱼rn的嗅觉皮层)的后部区域(postenor zorle)中的rn振荡嗅球活动的下游读出数据直接进行了研rn究.Dp神经元在很大程度上对同步振荡活动rn是不敏感的,但会对稳定态的活动做出反应.rn这些发现用Dp神经元的像过滤器一样的"低rn通"(low-pass)生物物理性质有可能得到解rn释,同时也说明了过滤作用何以能提取出神经rn元编码的个别成分.%Neuronal activity patterns contain information in their temporal structure, indicating that information transfer between neurons may be optimized by temporal filtering. In the zebrafish olfactory bulb, subsets of output neurons (mitral cells) engage in synchronized oscillations during odour responses, but information about odour identity is contained mostly in non-oscillatory firing rate patterns. Using optogenetic manipulations and odour stimulation, we found that firing rate responses of neurons in the posterior zone of the dorsal telencephalon (Dp), a target area homologous to olfactory cortex, were largely insensitive to oscillatory synchrony of mitral cells because passive membrane properties and synaptic currents act as low-pass filters. Nevertheless, synchrony influenced spike timing. Moreover, Dp neurons responded primarily during the decorrelated steady state of mitral cell activity patterns. Temporal filtering therefore tunes Dp neurons to components of mitral cell activity patterns that are particularly informative about precise odour identity. These results demonstrate how temporal filtering can extract specific information from multiplexed neuronal codes.

著录项

  • 来源
    《Nature》 |2011年第7374期|p.493-498A1|共7页
  • 作者

    Francisca Blumhagen; Peixin Zhu; Jennifer Shum; Yan-Ping Zhang Scharer; Emre Yaksi; Karl Deisseroth; Rainer W. Friedrich;

  • 作者单位

    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66,4058 Basel, Switzerland,Novartis Pharma GmbH, 90327 Nuremberg, Germany (F.B.);

    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66,4058 Basel, Switzerland;

    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66,4058 Basel, Switzerland,Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA (J.S.);

    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66,4058 Basel, Switzerland;

    Neuroelectronics Research Flanders, Kapeldreef 75,3001 Leuven, Belgium;

    Department of Bioengineering, Stanford University, Stanford, California 94305, USA;

    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66,4058 Basel, Switzerland,University of Basel, 4003 Basel, Switzerland;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号