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首页> 外文期刊>Nature >Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules
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Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules

机译：树突状细胞通过高内皮小静脉控制淋巴细胞进入淋巴结

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While patrolling the body in search of foreign antigens, naive lymphocytes continuously circulate from the blood, through the lymph nodes, into the lymphatic vessels and back to the blood1'2. This process, called lymphocyte recirculation, provides the body with effective immune surveillance for foreign invaders and for alterations to the body's own cells. However, the mechanisms that regulate lymphocyte recirculation during homeostasis remain incompletely characterized. Here we show that dendritic cells (DCs), which are well known for their role in antigen presentation to T lymphocytes3, control the entry of naive lymphocytes to lymph nodes by modulating the phenotype of high endothelial venules (HEVs), which are blood vessels specialized in lymphocyte recruitment245. We found that in vivo depletion of CD 1 lc+ DCs in adult mice over a 1-week period induces a reduction in the size and cellularity of the peripheral and mucosal lymph nodes. In the absence of DCs, the mature adult HEV phenotype reverts to an immature neonatal phenotype, and HEV-mediated lymphocyte recruitment to lymph nodes is inhibited. Co-culture experiments showed that the effect of DCs on HEV endothelial cells is direct and requires lymphotoxin-P-receptor-dependent signalling. DCs express lymphotoxin, and DC-derived lymphotoxin is important for lymphocyte homing to lymph nodes in vivo. Together, our results reveal a previously unsuspected role for DCs in the regulation of lymphocyte recirculation during immune surveillance.
机译：当在人体中巡逻以寻找外源抗原时，幼稚的淋巴细胞不断地从血液中循环通过淋巴结，进入淋巴管，然后回到血液1'2。这一过程称为淋巴细胞再循环，可为人体提供有效的免疫监视，以监测外来入侵者以及人体自身细胞的变化。但是，在稳态过程中调节淋巴细胞再循环的机制仍然不完整。在这里，我们显示树突状细胞（DCs）以其在T淋巴细胞抗原呈递中的作用而众所周知，3通过调节高内皮小静脉（HEVs）的表型来控制幼稚淋巴细胞进入淋巴结，这是血管特异性的245。我们发现，成年小鼠体内CD 1lc + DC的体内耗竭在1周的时间内可诱导外周和粘膜淋巴结的大小和细胞减少。在没有DC的情况下，成熟的成人HEV表型恢复为不成熟的新生儿表型，并且HEV介导的淋巴细胞募集到淋巴结受到抑制。共培养实验表明DC对HEV内皮细胞的影响是直接的，需要淋巴毒素P受体依赖性信号传导。 DC表达淋巴毒素，DC衍生的淋巴毒素对于体内归巢到淋巴结的淋巴细胞很重要。总之，我们的结果揭示了DC在免疫监视过程中对淋巴细胞再循环的调节中此前未曾想到的作用。

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  • 来源
    《Nature》 |2011年第7374期|p.542-546|共5页
  • 作者

    Christine Moussion; Jean-Philippe Girard;

  • 作者单位

    CNRS, Instituted Pharmacologieetde Biologie Structural,205 routede Narbonne,F-31077Toulouse, France,UniversitedeToulouse, UPS, Institutde PharmacologieetdeBiologieStructurale. F-31077 Toulouse, France;

    CNRS, Instituted Pharmacologieetde Biologie Structural,205 routede Narbonne,F-31077Toulouse, France,UniversitedeToulouse, UPS, Institutde PharmacologieetdeBiologieStructurale. F-31077 Toulouse, France;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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