Rethinking amide bond synthesis

Vijaya R. Pattabiraman; Jeffrey W. Bode

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Rethinking amide bond synthesis

机译：重新思考酰胺键的合成

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One of the most important reactions in organic chemistry-amide bond formation-is often overlooked as a contemporary challenge because of the widespread occurrence of amides in modern Pharmaceuticals and biologically active compounds. But existing methods are reaching their inherent limits, and concerns about their waste and expense are becoming sharper. Novel chemical approaches to amide formation are therefore being developed. Here we review and summarize a new generation of amide-forming reactions that may contribute to solving these problems. We also consider their potential application to current synthetic challenges, including the development of catalytic amide formation, the synthesis of therapeutic peptides and the preparation of modified peptides and proteins.

机译：在有机化学中最重要的反应之一-酰胺键的形成-由于现代药物和生物活性化合物中酰胺的广泛存在而经常被忽视，成为当今的挑战。但是，现有方法已达到其固有的极限，并且对它们的浪费和费用的担忧也越来越尖锐。因此，正在开发形成酰胺的新化学方法。在这里，我们回顾并总结了新一代酰胺形成反应，可能有助于解决这些问题。我们还考虑了它们在当前合成挑战中的潜在应用，包括开发催化酰胺形成，合成治疗性肽以及制备修饰的肽和蛋白质。

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来源
《Nature》 |2011年第7378期|p.471-479|共9页
作者
Vijaya R. Pattabiraman; Jeffrey W. Bode;
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作者单位

Laboratorium fuer Organische Chemie, ETH Zuerich, 8093 Zurich, Switzerland;

Laboratorium fuer Organische Chemie, ETH Zuerich, 8093 Zurich, Switzerland;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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5. Harnessing Cyclic Alkynes for the Synthesis of Heterocyclic Compounds and Nickel-Catalyzed C-C Bond Forming Reactions From Amide Derivatives. [D] . Medina, Jose Miguel. 2017

机译：利用环状炔烃合成杂环化合物和酰胺衍生物镍催化的C-C键形成反应。
6. Instability of Amide Bondwith Trifluoroacetic Acid(20): Synthesis Conformational Analysis and Mechanistic Insightsinto Cleavable Amide Bond Comprising β-TroponylhydrazinoAcid [O] . NiharRanjan Dalabehera, §, Sagarika Meher, 2020

机译：酰胺键的不稳定性用三氟乙酸（20％）：合成构象分析和机械洞察含有β-roTonyl氢芳基的可切割的酰胺键酸
7. Instability of Amide Bond with Trifluoroacetic Acid (20): Synthesis, Conformational Analysis, and Mechanistic Insights into Cleavable Amide Bond Comprising Troponylhydrazino Acid [O] . -1

机译：与三氟乙酸（20％）的酰胺键的不稳定性：合成，构象分析和机械洞察力酰胺酰胺粘合剂，其包含浓缩甲基酰基苯甲酸酯

Rethinking amide bond synthesis

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