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首页> 外文期刊>Nature >Innate production of T_H2 cytokines by adipose tissue-associated c-Kit~+Sca-1~+ lymphoid cells
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Innate production of T_H2 cytokines by adipose tissue-associated c-Kit~+Sca-1~+ lymphoid cells

机译：脂肪组织相关的c-Kit〜+ Sca-1〜+淋巴样细胞先天产生T_H2细胞因子

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摘要

Innate immune responses are important in combating various microbes during the early phases of infection. Natural killer (NK) cells are innate lymphocytes that, unlike T and B lymphocytes, do not express antigen receptors but rapidly exhibit cyto-toxic activities against virus-infected cells and produce various cytokines. Here we report a new type of innate lymphocyte present in a novel lymphoid structure associated with adipose tissues in the peritoneal cavity. These cells do not express lineage (Lin) markers but do express c-Kit, Sca-1 (also known as Ly6a), IL7R and IL33R. Similar lymphoid clusters were found in both human and mouse mesentery and we term this tissue 'FALC (fat-associated lymphoid cluster). FALC Lin~-c-Kit~+Sca-1~+ cells are distinct from lymphoid progenitors and lymphoid tissue inducer cells. These cells proliferate in response to IL2 and produce large amounts of T_H2 cytokines such as IL5, IL6 and IL13. IL5 and IL6 regulate B-cell antibody production and self-renewal of B1 cells. Indeed, FALC Lin~-c-Kit~+Sca-1~+ cells support the self-renewal of B1 cells and enhance IgA production. IL5 and IL13 mediate allergic inflammation and protection against helminth infection. After helminth infection and in response to IL33, FALC Lin~-c-Kit~+Sca-1~+ cells produce large amounts of IL13, which leads to goblet cell hyperplasia-a critical step for helminth expulsion. In mice devoid of FALC Lin~-c-Kit~+Sca-1~+ cells, such goblet cell hyperplasia was not induced. Thus, FALC Lin~-c-Kit~+Sca-1~+ cells are T_H2-type innate lymphocytes, and we propose that these cells be called 'natural helper cells'.
机译：在感染的早期阶段，先天免疫应答对于抵抗各种微生物很重要。天然杀伤（NK）细胞是先天性淋巴细胞，与T和B淋巴细胞不同，它们不表达抗原受体，但是对病毒感染的细胞迅速表现出细胞毒性，并产生各种细胞因子。在这里，我们报告一种新型的固有淋巴细胞存在于与腹膜腔脂肪组织相关的新型淋巴样结构中。这些细胞不表达谱系（Lin）标记，但表达c-Kit，Sca-1（也称为Ly6a），IL7R和IL33R。在人和小鼠的肠系膜中都发现了类似的淋巴样簇，我们称这种组织为'FALC（脂肪相关的淋巴样簇）。 FALC Lin〜-c-Kit〜+ Sca-1〜+细胞不同于淋巴样祖细胞和淋巴样组织诱导细胞。这些细胞响应IL2增殖并产生大量T_H2细胞因子，例如IL5，IL6和IL13。 IL5和IL6调节B细胞抗体的产生和B1细胞的自我更新。确实，FALC Lin〜-c-Kit〜+ Sca-1〜+细胞支持B1细胞的自我更新并增强IgA的产生。 IL5和IL13介导过敏性炎症并保护其免受蠕虫感染。蠕虫感染后并响应IL33，FALC Lin〜-c-Kit〜+ Sca-1〜+细胞产生大量IL13，导致杯状细胞增生，这是驱逐蠕虫的关键步骤。在没有FALC Lin〜-c-Kit〜+ Sca-1〜+细胞的小鼠中，这种杯状细胞不被增生。因此，FALC Lin〜-c-Kit〜+ Sca-1〜+细胞是T_H2型先天淋巴细胞，我们建议将这些细胞称为“天然辅助细胞”。

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  • 来源
    《Nature》 |2010年第7280期|540-544|共5页
  • 作者

    Kazuyo Moro; Taketo Yamada; Masanobu Tanabe; Tsutomu Takeuchi; Tomokatsu Ikawa; Hiroshi Kawamoto; Jun-ichi Furusawa; Masashi Ohtani; Hideki Fujii; Shigeo Koyasu;

  • 作者单位

    Department of Microbiology and immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan Japan Science and Technology Agency (JST), CREST, Chiyoda-ku, Tokyo 102-0075, Japan;

    Department of Pathology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan;

    Department of Tropical Medicine and Parasitology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan;

    Department of Tropical Medicine and Parasitology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan;

    Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan;

    Laboratory for Lymphocyte Development, Riken Research Center for Allergy and Immunology, Yokohama, Kanagawa 230-0045, Japan;

    Department of Microbiology and immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan;

    Department of Microbiology and immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan Department of Cell Signalling, Institute of Biomedical Science, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan;

    Department of Microbiology and immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan;

    Department of Microbiology and immunology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan Research Center for Science Systems, Japan Society for the Promotion of Science (JSPS), Chiyoda-ku, Tokyo 102-8472, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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