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Curvature in metabolic scaling

机译：代谢缩放中的曲率

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摘要

For more than three-quarters of a century it has been assumed1 that basal metabolic rate increases as body mass raised to some power p. However, there is no broad consensus regarding the value of p: whereas many studies have asserted that p is 3/4 (refs 1-4; 'Kleiber's law'), some have argued that it is 2/3 (refs 5-7), and others have found that it varies depending on factors like environment and taxonomy. Here we show that the relationship between mass and metabolic rate has convex curvature on a logarithmic scale, and is therefore not a pure power law, even after accounting for body temperature. This finding has several consequences. First, it provides an explanation for the puzzling variability in estimates of p, settling a long-standing debate. Second, it constitutes a stringent test for theories of metabolic scaling. A widely debated model based on vascular system architecture fails this test, and we suggest modifications that could bring it into compliance with the observed curvature. Third, it raises the intriguing question of whether the scaling relation limits body size.
机译：四分之三世纪以来，人们一直假设1基础代谢率会随着体重增加到某个幂p而增加。但是，关于p的值尚无广泛共识：尽管许多研究断言p为3/4（参考1-4；“克莱伯定律”），但有人认为p为2/3（参考5-7）。 ），其他人发现它会根据环境和分类法等因素而有所不同。在这里，我们表明质量和代谢率之间的关系在对数尺度上具有凸曲率，因此即使考虑了体温，也不是纯粹的幂律。这一发现有若干后果。首先，它为p估计中令人费解的可变性提供了解释，解决了长期以来的争论。其次，它构成了对代谢定标理论的严格测试。基于血管系统架构的广泛争议的模型未能通过该测试，我们建议进行修改，使其与观察到的曲率保持一致。第三，它引起了一个有趣的问题，即比例关系是否限制了身体的大小。

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  • 来源
    《Nature》 |2010年第7289期|753-756|共4页
  • 作者

    Tom Kolokotrones; Van Savage; Eric J. Deeds; Walter Fontana;

  • 作者单位

    Harvard Medical School, Boston, Massachusetts 02115, USA;

    David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, California 90024, USA;

    Harvard Medical School, Boston, Massachusetts 02115, USA;

    Harvard Medical School, Boston, Massachusetts 02115, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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