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The genome of a songbird

机译：鸣禽的基因组

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摘要

The zebra finch is an important model organism in several fields with unique relevance to human neuroscience. Like other songbirds, the zebra finch communicates through learned vocalizations, an ability otherwise documented only in humans and a few other animals and lacking in the chicken-the only bird with a sequenced genome until now. Here we present a structural, functional and comparative analysis of the genome sequence of the zebra finch (Taeniopygia guttata), which is a songbird belonging to the large avian order Passeriformes. We find that the overall structures of the genomes are similar in zebra finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene family expansions, the number of long-terminal-repeat-based retrotransposons, and mechanisms of sex chromosome dosage compensation. We show that song behaviour engages gene regulatory networks in the zebra finch brain, altering the expression of long non-coding RNAs, microRNAs, transcription factors and their targets. We also show evidence for rapid molecular evolution in the songbird lineage of genes that are regulated during song experience. These results indicate an active involvement of the genome in neural processes underlying vocal communication and identify potential genetic substrates for the evolution and regulation of this behaviour.
机译：斑马雀科是与人类神经科学具有独特关联的几个领域中的重要模式生物。像其他鸣禽一样，斑雀雀通过学习的发声方式进行交流，这种能力原本仅在人类和其他一些动物中才有记载，而在鸡中却是缺乏的。在这里，我们介绍了斑马雀（Taeniopygia guttata）的基因组序列的结构，功能和比较分析，斑马雀是属于大型禽类Passeriformes的鸣禽。我们发现斑马雀科和鸡的基因组总体结构相似，但是它们在许多染色体内重排，谱系特异性基因家族扩展，基于长末端重复的逆转录转座子的数量以及性染色体剂量的机制上有所不同赔偿。我们表明，歌曲行为会在斑马雀科的大脑中参与基因调控网络，从而改变长非编码RNA，microRNA，转录因子及其靶标的表达。我们还显示了在歌曲体验期间受调节的基因的鸣鸟谱系中快速分子进化的证据。这些结果表明基因组积极参与了声音交流背后的神经过程，并确定了这种行为的进化和调控的潜在遗传底物。

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  • 来源
    《Nature》 |2010年第7289期|757-762|共6页
  • 作者

    Wesley C. Warren; David F. Clayton; Hans Ellegren; Arthur P. Arnold; LaDeana W. Hillier; et al;

  • 作者单位

    The Genome Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA;

    University of Illinois, Urbana-Champaign, Illinois 61801 USA;

    Uppsala University, Institute for Evolution and Genetics Systems, Norbyvagen 18D 752 36 Uppsala, Sweden;

    University of California- Los Angeles, Los Angeles, California 90056, USA;

    The Genome Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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