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NINJA connects the co-repressor TOPLESS to jasmonate signalling

机译：NINJA将辅助抑制器TOPLESS连接到茉莉信号

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摘要

Jasmonoyl-isoleucine (JA-Ile) is a plant hormone that regulates a broad array of plant defence and developmental processes. JA-Ile-responsive gene expression is regulated by the transcriptional activator MYC2 that interacts physically with the jasmonate ZIM-domain (JAZ) repressor proteins. On perception of JA-Ile, JAZ proteins are degraded and JA-Ile-dependent gene expression is activated. The molecular mechanisms by which JAZ proteins repress gene expression remain unknown. Here we show that the Arabidopsis JAZ proteins recruit the Groucho/Tupl-type co-repressor TOPLESS (TPL) and TPL-related proteins (TPRs) through a previously uncharacterized adaptor protein, designated Novel Interactor of JAZ (NINJA). NINJA acts as a transcriptional repressor whose activity is mediated by a functional TPL-binding EAR repression motif. Accordingly, both NINJA and TPL proteins function as negative regulators of jasmonate responses. Our results point to TPL proteins as general co-repressors that affect multiple signalling pathways through the interaction with specific adaptor proteins. This new insight reveals how stress-related and growth-related signalling cascades use common molecular mechanisms to regulate gene expression in plants.
机译：茉莉基异亮氨酸（JA-Ile）是一种植物激素，可调节多种植物防御和发育过程。 JA-Ile响应基因表达受转录激活因子MYC2调控，该转录激活因子与茉莉酸的ZIM域（JAZ）阻遏蛋白发生物理相互作用。在感知到JA-Ile时，JAZ蛋白被降解并且JA-Ile依赖性基因表达被激活。 JAZ蛋白抑制基因表达的分子机制仍然未知。在这里，我们显示拟南芥JAZ蛋白通过以前未鉴定的衔接子蛋白（称为JAZ新型相互作用子（NINJA））募集了Groucho / Tupl型共阻遏物TOPLESS（TPL）和TPL相关蛋白（TPRs）。 NINJA充当转录阻遏物，其活性由功能性TPL结合EAR抑制基序介导。因此，NINJA和TPL蛋白均充当茉莉酸酯响应的负调节剂。我们的结果指出，TPL蛋白是一般的共抑制因子，通过与特定衔接蛋白的相互作用影响多种信号通路。这一新见解揭示了胁迫相关和生长相关的信号传导级联如何利用常见的分子机制来调节植物中的基因表达。

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  • 来源
    《Nature》 |2010年第7289期|788-791|共4页
  • 作者

    Laurens Pauwels; Gemma Fernandez Barbero; Jan Geerinck; Sofie Tilleman; Wim Grunewald; Amparo Cuellar Perez; Jose Manuel Chico; Robin Vanden Bossche; Jared Sewell; Eduardo Gil; Gloria Garcia-Casado; Erwin Witters; Dirk Inze; Jeff A. Long; Geert De Jaeger; Roberto Solano; Alain Goossens;

  • 作者单位

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium;

    Departamento de Genetica Molecular de Plantas, Campus Universidad Autonoma, 28049 Madrid, Spain;

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium;

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium;

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Gent, Belgium;

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium;

    Departamento de Genetica Molecular de Plantas, Campus Universidad Autonoma, 28049 Madrid, Spain;

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium;

    Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA;

    Genomics Unit, Centro Nacional de Biotecnologia-CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain;

    Genomics Unit, Centro Nacional de Biotecnologia-CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain;

    Department of Biology, EBT-CEPROMA, University of Antwerp, Groenenborgerlaan 171, B-2020 Antwerpen, Belgium Flemish Institute for Technological Research VITO-MANT, Boeretang 200, B-2400 Mol, Belgium;

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium;

    Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA;

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium;

    Departamento de Genetica Molecular de Plantas, Campus Universidad Autonoma, 28049 Madrid, Spain Genomics Unit, Centro Nacional de Biotecnologia-CSIC, Campus Universidad Autonoma, 28049 Madrid, Spain;

    Department of Plant Systems Biology, Flanders Institute for Biotechnology (VIB), Technologiepark 927, B-9052 Gent, Belgium Department of Plant Biotechnology and Genetics, Ghent University, Technologiepark 927, B-9052 Gent, Belgium;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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