首页> 外国专利> SMRT co-repressors, transcriptional co-repressors that interact with nuclear hormone receptors

SMRT co-repressors, transcriptional co-repressors that interact with nuclear hormone receptors

机译:SMRT协同阻遏物,与核激素受体相互作用的转录协同阻遏物

摘要

The present invention relates to isolated polynucleotides encoding a family of silencing mediators of retinoic acid and thyroid hormone receptor (SMRT) isoforms, including vertebrate and invertebrate isoforms thereof. The invention also relates to polypeptide SMRT co-repressors encoded by invention SMRT polynucleotides, and to peptide portions thereof that can modulate transcriptional potential of a nuclear receptor. In addition, the invention relates to chimeric molecules and to complexes containing a SMRT co-repressor or peptide portion thereof, to antibodies that specifically bind such compositions, and to methods for identifying an agent that modulates the repressor potential of a SMRT co-repressor. The invention also provides methods for identifying an agent that modulates a function of a SMRT co-repressor; for modulating the transcriptional potential of a nuclear receptor in a cell using the compositions of the invention; and for identifying a molecule that interacts specifically with a SMRT co-repressor.
机译:本发明涉及编码视黄酸和甲状腺激素受体(SMRT)同工型的沉默介体家族的分离的多核苷酸,包括其脊椎动物和无脊椎动物同工型。本发明还涉及由本发明SMRT多核苷酸编码的多肽SMRT共阻遏物,以及涉及其可调节核受体转录潜能的肽部分。另外,本发明涉及嵌合分子和含有SMRT共抑制子或其肽部分的复合物,特异性结合此类组合物的抗体,以及鉴定调节SMRT共抑制子的阻遏子潜能的试剂的方法。本发明还提供了鉴定调节SMRT共抑制子功能的试剂的方法。使用本发明的组合物调节细胞中核受体的转录潜能;用于鉴定与SMRT共抑制子特异性相互作用的分子。

著录项

相似文献

  • 专利
  • 外文文献
  • 中文文献
获取专利

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号