• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >IL25 elicits a multipotent progenitor cell population that promotes T_H2 cytokine responses
【24h】

IL25 elicits a multipotent progenitor cell population that promotes T_H2 cytokine responses

机译：IL25诱导多能祖细胞群，促进T_H2细胞因子反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

CD4~+ T helper 2 (T_H2) cells secrete interleukin (IL)4, IL5 and IL13, and are required for immunity to gastrointestinal helminth infections. However, T_H2 cells also promote chronic inflammation associated with asthma and allergic disorders. The non-haematopoietic-cell-derived cytokines thymic stromal lympho-poietin, IL33 and IL25 (also known as IL17E) have been implicated in inducing T_H2 cell-dependent inflammation at mucosal sites, but how these cytokines influence innate immune responses remains poorly defined. Here we show that IL25, a member of the IL17 cytokine family, promotes the accumulation of a lineage-negative (Lin~-) multipotent progenitor (MPP) cell population in the gut-associated lymphoid tissue that promotes T_H2 cytokine responses. The IL25-elicited cell population, termed MPP~(type2) cells, was defined by the expression of Sca-1 (also known as Ly6a) and intermediate expression of c-Kit (c-Kit~(int)), and exhibited multipotent capacity, giving rise to cells of monocyte/macro-phage and granulocyte lineages both in vitro and in vivo. Progeny of MPP~(type2) cells were competent antigen presenting cells, and adoptive transfer of MPP~(type2) cells could promote T_H2 cytokine responses and confer protective immunity to helminth infection in normally susceptible Il25~(-/-) mice. The ability of IL25 to induce the emergence of an MPP~(type2) cell population identifies a link between the IL17 cytokine family and extramedullary haemato-poiesis, and suggests a previously unrecognized innate immune pathway that promotes T_H2 cytokine responses at mucosal sites.
机译：CD4〜+ T辅助2（T_H2）细胞分泌白介素（IL）4，IL5和IL13，是抵抗胃肠蠕虫感染的免疫力所必需的。但是，T_H2细胞也促进与哮喘和过敏性疾病有关的慢性炎症。非造血细胞源性细胞因子胸腺基质淋巴细胞生成素，IL33和IL25（也称为IL17E）与粘膜部位T_H2细胞依赖性炎症的发生有关，但这些细胞因子如何影响先天性免疫应答仍不清楚。在这里，我们显示IL25，IL17细胞因子家族的一员，促进肠道相关淋巴样组织中谱系阴性（Lin〜-）多能祖细胞（MPP）的积累，从而促进T_H2细胞因子的反应。 IL25诱导的细胞群称为MPP〜（type2）细胞，由Sca-1（也称为Ly6a）的表达和c-Kit的中间表达（c-Kit〜（int））定义，并表现出多能性在体外和体内都会产生单核细胞/巨噬细胞和粒细胞系的细胞。 MPP〜（2型）细胞的后代是感受态抗原呈递细胞，MPP〜（2型）细胞的过继转移可以促进T_H2细胞因子反应，并在正常易感的Il25〜（-/-）小鼠中对蠕虫感染提供保护性免疫。 IL25诱导MPP〜（type2）细胞群体出现的能力确定了IL17细胞因子家族与髓外血细胞生成之间的联系，并暗示了以前未被认识的先天免疫途径，可促进粘膜位点的T_H2细胞因子反应。

著录项

  • 来源
    《Nature》 |2010年第7293期|p.1362-1366|共5页
  • 作者

    Steven A. Saenz; Mark C. Siracusa; Jacqueline G. Perrigoue; Sean P. Spencer; Joseph F. Urban Jr; Joel E. Tocker; Alison L. Budelsky; Melanie A. Kleinschek; Robert A. Kastelein; Taku Kambayashi; Avinash Bhandoola; David Artis;

  • 作者单位

    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Diet, Genomics, & Immunology Lab, Beltsville Human Nutrition Research Center, US Department of Agriculture, Beltsville, Maryland 20705, USA;

    Department of Inflammation Research, Amgen, Seattle, Washington 98119, USA;

    Department of Inflammation Research, Amgen, Seattle, Washington 98119, USA;

    Discovery Research, Schering-Plough Biopharma, Palo Alto, California 94304, USA;

    Discovery Research, Schering-Plough Biopharma, Palo Alto, California 94304, USA;

    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

    Department of Pathobiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号