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首页> 外文期刊>Nature >Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization
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Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization

机译：表皮葡萄球菌Esp抑制金黄色葡萄球菌生物膜形成和鼻部定植

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摘要

Commensal bacteria are known to inhibit pathogen colonization; however, complex host-microbe and microbe-microbe interactions have made it difficult to gain a detailed understanding of the mechanisms involved in the inhibition of colonization. Here we show that the serine protease Esp secreted by a subset of Staphylococcus epidermidis, a commensal bacterium, inhibits biofilm formation and nasal colonization by Staphylococcus aureus, a human pathogen. Epidemiological studies have demonstrated that the presence of Esp-secreting S. epidermidis in the nasal cavities of human volunteers correlates with the absence of S. aureus. Purified Esp inhibits biofilm formation and destroys pre-existing S. aureus biofilms. Furthermore, Esp enhances the susceptibility of S. aureus in biofilms to immune system components. In vivo studies have shown that Esp-secreting S. epidermidis eliminates S. aureus nasal colonization. These findings indicate that Esp hinders S. aureus colonization in vivo through a novel mechanism of bacterial interference, which could lead to the development of novel therapeutics to prevent S. aureus colonization and infection.
机译：众所周知，共生细菌可以抑制病原体的定殖。然而，复杂的宿主-微生物和微生物-微生物相互作用使得难以深入了解抑制定植的机制。在这里，我们显示了由表皮葡萄球菌（一种共生细菌）分泌的丝氨酸蛋白酶Esp抑制生物膜的形成和金黄色葡萄球菌（一种人类病原体）的鼻部定植。流行病学研究表明，在人类志愿者的鼻腔中存在分泌Esp的表皮葡萄球菌与缺乏金黄色葡萄球菌有关。纯化的Esp可抑制生物膜形成并破坏先前存在的金黄色葡萄球菌生物膜。此外，Esp增强了生物膜中金黄色葡萄球菌对免疫系统组件的敏感性。体内研究表明，分泌Esp的表皮葡萄球菌消除了金黄色葡萄球菌的鼻部定植。这些发现表明，Esp通过一种新型的细菌干扰机制在体内阻碍了金黄色葡萄球菌的定植，这可能导致开发出预防金黄色葡萄球菌定植和感染的新型疗法。

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  • 来源
    《Nature》 |2010年第7296期|p.346-349|共4页
  • 作者

    Tadayuki Iwase; Yoshio Uehara; Hitomi Shinji; Akiko Tajima; Hiromi Seo; Koji Takada; Toshihiko Agata; Yoshimitsu Mizunoe;

  • 作者单位

    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan;

    Department of General Medicine, Kochi Medical School, Nankoku, 783-8505 Japan;

    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan;

    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan;

    Department of General Medicine, Kochi Medical School, Nankoku, 783-8505 Japan;

    Department of Biochemistry, The Jikei University School of Medicine, Tokyo, 105-8461 Japan;

    Department of Environmental Health, The Jikei University School of Medicine, Tokyo 105-8461 Japan;

    Department of Bacteriology, The Jikei University School of Medicine, Tokyo, 105-8461 Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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