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Co-option of the hormone-signalling module dafachronic acid-DAF-12 in nematode evolution

机译：线虫进化过程中激素信号转导模块大发链酸DAF-12的共同选择

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摘要

Morphological novelties are lineage-specific traits that serve new functions. Developmental polyphenisms have been proposed to be facilitators of phenotypic evolution, but little is known about the interplay between the associated genetic and environmental factors. Here, we study two alternative morphologies in the mouth of the nematode Pristionchus pacificus and the formation of teeth-like structures that are associated with bacteriovorous feeding and predatory behaviour on fungi and other worms12"16. These teeth-like denticles represent an evolutionary novelty, which is restricted to some members of the nematode family Diplogastridae but is absent from Caenorhabditis elegans and related nematodes. We show that the mouth dimorphism is a polyphenism that is controlled by starvation and the co-option of an endocrine switch mechanism. Mutations in the nuclear hormone receptor DAF-12 and application of its ligand, the sterol hormone dafachronic acid, strongly influence this switch mechanism. The dafachronic acid-DAF-12 module has been shown to control the formation of arrested dauer larvae in both C. elegans and P. pacificus, as well as related life-history decisions in distantly related nematodes. The comparison of dauer formation and mouth morphology switch reveals that different thresholds of dafachronic acid signalling provide specificity. This study shows how hormonal signalling acts by coupling environmental change and genetic regulation and identifies dafachronic acid as a key hormone in nematode evolution.
机译：形态学上的新奇是特定于世袭的特征，具有新的功能。已提出发育多态性是表型进化的促进剂，但有关遗传和环境因素之间的相互作用知之甚少。在这里，我们研究了线虫Pristionchus pacificus口中的两种替代形态，以及与细菌和其他蠕虫上的细菌食性和掠食行为相关的牙齿状结构的形成[12]。这些牙齿状细齿代表了一种进化的新颖性，它仅限于线虫科Diplogastridae的某些成员，但秀丽隐杆线虫和相关线虫中不存在。我们表明，口腔二态性是受饥饿和内分泌转换机制的共同控制的多态性。激素受体DAF-12及其配体，甾醇激素大发古龙酸的应用，强烈影响这种转换机制，已证明大发古龙酸-DAF-12模块可控制秀丽隐杆线虫和P.的滞留幼虫的形成。远缘线虫的太平洋以及相关的生活史决策道尔形成与口腔吗啡的比较ogy switch揭示了不同的dafachronic acid信号传递阈值提供了特异性。这项研究显示了激素信号如何通过耦合环境变化和遗传调控而发挥作用，并确定大发酸是线虫进化中的关键激素。

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  • 来源
    《Nature》 |2010年第7305期|P.494-497|共4页
  • 作者

    Gilberto Bento; Akira Ogawa; Ralf J. Sommer;

  • 作者单位

    Department for Evolutionary Biology, Max-Planck-lnstitute for Developmental Biology, Spemannstrasse 37 D-72076 Tubingen, Germany;

    rnDepartment for Evolutionary Biology, Max-Planck-lnstitute for Developmental Biology, Spemannstrasse 37 D-72076 Tubingen, Germany;

    rnDepartment for Evolutionary Biology, Max-Planck-lnstitute for Developmental Biology, Spemannstrasse 37 D-72076 Tubingen, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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