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On-line, voluntary control of human temporal lobe neurons

机译:在线,自愿控制人类颞叶神经元

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摘要

Daily life continually confronts us with an exuberance of external, sensory stimuli competing with a rich stream of internal deliberations, plans and ruminations. The brain must select one or more of these for further processing. How this competition is resolved across multiple sensory and cognitive regions is not known; nor is it clear how internal thoughts and attention regulate this competition. Recording from single neurons in patients implanted with intracranial electrodes for clinical reasons, here we demonstrate that humans can regulate the activity of their neurons in the medial temporal lobe (MTL) to alter the outcome of the contest between external images and their internal representation. Subjects looked at a hybrid superposition of two images representing familiar individuals landmarks, objects or animals and had to enhance one image at the expense of the other, competing one. Simultaneously, the spiking activity of their MTL neurons in different subregions and hemispheres was decoded in real time to control the content of the hybrid. Subjects reliably regulated, often on the first trial, the firing rate of their neurons, increasing the rate of some while simultaneously decreasing the rate of others. They did so by focusing onto one image, which gradually became clearer on the computer screen in front of their eyes, and thereby overriding sensory input. On the basis of the firing of these MTL neurons, the dynamics of the competition between visual images in the subject's mind was visualized on an external display.
机译:日常生活不断以丰富的外部感官刺激与内部的思考,计划和反省相竞争。大脑必须选择其中一个或多个以进行进一步处理。尚不清楚如何在多个感觉和认知区域解决这种竞争;也不清楚内部的思想和注意力如何调节这场竞争。出于临床原因,从植入颅内电极的患者的单个神经元记录下来,这里我们证明了人类可以调节内侧颞叶(MTL)中神经元的活性,从而改变外部图像与其内部表征之间的竞争结果。受试者观看了代表熟悉的个人地标,物体或动物的两幅图像的混合叠加,不得不以牺牲另一幅图像为代价来增强一张图像,以竞争另一幅图像。同时,实时解码了它们在不同分区和半球中的MTL神经元的突触活性,以控制杂种的含量。通常在第一次试验中,受试者就可靠地调节了神经元的放电速率,从而增加了某些神经元的放电率,同时降低了其他神经元的放电率。他们通过聚焦在一张图像上来做到这一点,这些图像在他们眼前的计算机屏幕上逐渐变得清晰,从而覆盖了感觉输入。基于这些MTL神经元的发射,在外部显示器上可视化了受试者大脑中视觉图像之间竞争的动态。

著录项

  • 来源
    《Nature》 |2010年第7319期|p.1104-1108|共5页
  • 作者单位

    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA,Department of Neurosurgery, University of California, Los Angeles, California 90095, USA,Stern School of Business, New York University, New York, New York 10012, USA;

    rnComputation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA,School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA;

    rnComputation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA,Department of Epileptology, University of Bonn, Bonn 53105, Germany;

    rnComputation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA;

    rnComputation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA,Department of Engineering, University of Leicester, Leicester LE1 7RH, UK;

    rnComputation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA,Department of Brain and Cognitive Engineering, Korea University, Seoul, 136-713, Korea;

    rnDepartment of Neurosurgery, University of California, Los Angeles, California 90095, USA,Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, USA,Functional Neurosurgery Unit, Tel-Aviv Medical Center Tel-Aviv 64239, Israel,Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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