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The intestinal-crypt casino

机译:小肠隐窝赌场

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摘要

Certain tissues, such as the skin, blood and intestinal lining, replenish millions of lost cells every day. The burden of renewal falls on small populations of stem cells, which can make exact copies of themselves, as well as generate all the resident cell types that differentiate and eventually die. This rare dual ability, a defining property of all stem cells, is exemplified by the asymmetrical division of germ cells and neuronal precursors in the fruitfly. Nonetheless, as long as the total stem-cell pool in a tissue remains roughly constant, in principle there is no reason why individual stem cells should not divide symmetrically, to generate either two identical stem cells or two daughters that exit the pool to differentiate. Indeed, two reports published in Science and Cell demonstrate that, in the normal course of tissue renewal, intestinal stem cells divide symmetrically.
机译:某些组织(例如皮肤,血液和肠壁)每天补充数百万个丢失的细胞。更新的重担落在了少量的干细胞上,这些干细胞可以自我复制,并产生所有分化并最终死亡的常驻细胞类型。这种罕见的双重能力是所有干细胞的决定性特性,在果蝇中生殖细胞和神经元前体的不对称分裂就是例证。尽管如此,只要组织中的总干细胞池保持大致恒定,原则上就没有理由为什么单个干细胞不应该对称分裂以产生两个相同的干细胞或两个离开池而分化的子代。实际上,《科学》和《细胞》杂志上发表的两篇报道表明,在正常的组织更新过程中,肠干细胞对称分裂。

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  • 来源
    《Nature》 |2010年第7319期|p.1055-1056|共2页
  • 作者单位

    Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA Department of Medicine, Brigham & Women's Hospital and Harvard Medical School;

    rnDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA Department of Medicine, Brigham & Women's Hospital and Harvard Medical School;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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