Good And Bad Cell Death

Donald W. Nicholson

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Good And Bad Cell Death

机译：好与坏细胞死亡

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A major driver of neurodegeneration in Alzheimer's disease is thought to be plaques of amyloid-β peptides. These 40-42-amino-acid fragments form when the transmem-brane amyloid-β precursor protein (APP) is degraded by the enzymes β- and y-secretase. In addition to amyloid-β peptides, degradation of APP results in the formation of other peripheral fragments. Perhaps unsurprisingly, given the compelling link between the deposition of amyloid-β peptides and the development of Alzheimer's disease, these additional fragments have been outshone and have received scant attention. But on page 981 of this issue, Nikolaev and colleagues report that one oft-neglected fragment - the soluble amino-terminal portion of APP (N-APP) - has a crucial role in fine-sculpting of the nervous system during development, and possibly in disease-associated neurodegeneration as well.

机译：人们认为，阿尔茨海默氏病神经退行性病变的主要驱动因素是淀粉样β肽斑块。当跨膜淀粉样β-前体蛋白（APP）被β-和γ-分泌酶降解时，就会形成这些40-42个氨基酸的片段。除β淀粉样蛋白肽外，APP的降解还导致其他外周片段的形成。考虑到淀粉样蛋白-β肽的沉积与阿尔茨海默氏病的发展之间存在着令人信服的联系，也许不足为奇，这些额外的片段已经过时了，受到了很少的关注。但是在此问题的第981页上，尼古拉耶夫及其同事报告说，一个经常被忽略的片段-APP的可溶性氨基末端部分（N-APP）-在发育过程中对神经系统的精细雕刻中起着至关重要的作用，甚至可能在疾病相关的神经变性中也是如此。

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《Nature》 |2009年第7232期|970-971|共2页
作者
Donald W. Nicholson;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. Overexpression of copper/zinc superoxide dismutase in transgenic mice protects against neuronal cell death after transient focal ischemia by blocking activation of the Bad cell death signaling pathway. [J] . Saito A, Hayashi T, Okuno S, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2003,第5期

机译：转基因小鼠中铜/锌超氧化物歧化酶的过表达通过阻断坏死细胞死亡信号传导途径的激活，在短暂性局灶性缺血后预防神经元细胞死亡。
2. Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway [J] . Shu-Fen Peng, Chao-Ying Lee, Mann-Jen Hour, International journal of oncology . 2013,第1期

机译：姜黄素负载的纳米颗粒通过Akt-Bad信号通路增强U2OS人骨肉瘤细胞的凋亡
3. The roles of cyclic AMP-ERK-Bad signaling pathways on 6-hydroxydopamine-induced cell survival and death in PC12 cells [J] . ParkH.J., ParkK.H., ShinK.S., Toxicology in vitro: an international journal published in association with BIBRA . 2013,第8期

机译：环状AMP-ERK-Bad信号通路在6-羟基多巴胺诱导的PC12细胞存活和死亡中的作用
4. Cytological features of programmed cell death in Nicotiana tabacum cells in relation tothe expression and localization of death regulators [C] . Louise Brisson, Nathalie Bolduc, Mario Ouellet, Microscopy Society of America annual meeting;Microscopy Society of Canada annual meeting;Societe de Microscopie du Canada annual meeting;Microbeam Analysis Society annual meeting;International Metallographic Society annual meeting . 2002

机译：烟草细胞中程序性细胞死亡的细胞学特征与死亡调节因子的表达和定位有关
5. The STING of death in T cells: IFN responses and cell death result from activation of T cell STING [D] . Larkin, Bridget 2017

机译：T细胞死亡的STING：T细胞STING的激活导致IFN反应和细胞死亡
6. The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins [O] . Joshua Munger, Bernard Roizman 2001

机译：单纯疱疹病毒1的US3蛋白激酶介导BAD的翻译后修饰并在没有其他病毒蛋白的情况下防止BAD诱导的程序性细胞死亡
7. The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins [O] . Munger, Joshua, Roizman, Bernard 2001

机译：单纯疱疹病毒1的US3蛋白激酶介导BAD的翻译后修饰，并在没有其他病毒蛋白的情况下防止BAD诱导的程序性细胞死亡

Good And Bad Cell Death

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