Exome sequencing takes centre stage in cancer profiling

Brendan Maher

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Exome sequencing takes centre stage in cancer profiling

机译：外显子组测序在癌症分析中处于核心地位

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To help battle their way through the stream of data coining in from human gene sequencing, major cancer-genome screening projects such as the International Cancer Genome Consortium (ICGC) seem to be choosing to simplify matters.rnThe ICGC aims eventually to sequence the full genomes of 25,000 tumour samples as well as those of the people from whom the tumours were taken, which would give 50,000 distinct genomes.rnBut in the near term, the project is doing targeted sequencing of just the 1% of the genome knownrnto code for proteins - the 'exons' within genes.

机译：为了帮助解决人类基因测序产生的数据流中的难题，国际癌症基因组联盟（ICGC）等主要癌症基因组筛选项目似乎正在选择简化事情.rn ICGC最终旨在对整个基因组进行测序包括25,000个肿瘤样本以及从中获取肿瘤的人群的样本，这些样本将提供50,000个不同的基因组。rn但在不久的将来，该项目仅对已知编码蛋白质的1％的基因组进行了靶向测序-基因中的“外显子”。

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《Nature》 |2009年第7244期|146-147|共2页
作者
Brendan Maher;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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1. 19?Whole-exome sequencing based immunogenomic profiling with potential clinical applicability in circulating cell-free DNA and tissue from advanced stage colorectal cancer patients [J] . Zheng Feng, Juergen Scheuenpflug, Mengyao Tan, Journal for ImmunoTherapy of Cancer . 2020,第Suppla3期

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2. Whole-exome sequencing and immune profiling of early-stage lung adenocarcinoma with fully annotated clinical follow-up (vol 28, pg 75, 2017) [J] . Kadara H., Choi M., Zhang J., Annals of oncology: official journal of the European Society for Medical Oncology . 2018,第4期

机译：早期肺腺癌的全外膜测序和免疫分析，具有完全注释的临床随访（Vol 28，PG 75,2017）
3. Whole-Exome Sequencing-Based Mutational Profiling of Hepatitis B Virus-Related Early-Stage Hepatocellular Carcinoma [J] . Hao Zhan, Jiahao Jiang, Qiman Sun, Gastroenterology research and practice . 2017,第Pta1期

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4. A Chromosome-Centric Protein-Protein Interaction Profiling of MS-Based Proteome Datasets Derived from Laser-Microdissected Cancerous Cells of Lung Cancer Subtypes [C] . Kiyonaga Fujii, Hiroyuki Kimura, Hideki Marushima, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：一种以染色体为中心的蛋白质 - 蛋白质 - 蛋白质 - 蛋白质 - 蛋白质蛋白质相互作用，其来自肺癌亚型激光微小癌细胞的激光微小癌细胞
5. Flow-sorting of Hodgkin Reed-Sternberg cells, low-input sequencing, and bioinformatic profiling: Methodological development and characterization of cancer exomes and transcriptomes [D] . Reichel, Jonathan B. 2015

机译：Hodgkin Reed-Sternberg细胞的流分类，低投入测序和生物信息学分析：癌症外显子组和转录组的方法学开发和表征
6. Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage [O] . G Corda, A Sala 2017

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7. Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis [O] . Timmermann, Bernd, Kerick, Martin, Roehr, Christina, 2010

机译：通过全基因组下一代测序和生物信息学分析鉴定MSI和MSS大肠癌的体细胞突变谱。

Exome sequencing takes centre stage in cancer profiling

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