Synthetic lessons from nature

Huw M. L. Davies

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Synthetic lessons from nature

机译：大自然的综合教训

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Most syntheses in organic chemistry target one molecule, or a few closely related analogues at most. But by taking a leaf from nature's book, the latest synthetic strategy opens the door to a whole family of compounds.rnNaturally occurring compounds - known as 'natural products' to chemists - have had a long-standing role in the process of drug discovery. Many of them have useful biological activities and have become the foundations of new classes of therapeutic agents. A severe constraint on such efforts, however, is the limited availability of many natural products, which are often present in vanishingly small quantities in their native organisms.

机译：有机化学中的大多数合成最多只能靶向一个分子或几个紧密相关的类似物。但是，通过从自然界的书上摘取叶子，最新的合成策略为整个化合物家族打开了大门。天然存在的化合物-化学家称为“天然产物”-在药物发现过程中一直发挥着长期作用。它们中的许多具有有用的生物学活性，并已成为新型治疗剂的基础。然而，对这种努力的严重限制是许多天然产物的供应有限，这些天然产物通常以很少的量存在于其天然生物中。

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《Nature》 |2009年第7248期|786-787|共2页
作者
Huw M. L. Davies;
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Department of Chemistry, Emory University, 440 Atwood Hall, Atlanta, Georgia 30322, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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Synthetic lessons from nature

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