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Two types of dopamine neuron distinctly convey positive and negative motivational signals

机译：两种类型的多巴胺神经元分别传达积极和消极的动机信号

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摘要

Midbrain dopamine neurons are activated by reward or sensory stimuli predicting reward. These excitatory responses increase as the reward value increases5. This response property has led to a hypothesis that dopamine neurons encode value-related signals and are inhibited by aversive events. Here we show that this is true only for a subset of dopamine neurons. We recorded the activity of dopamine neurons in monkeys (Macaca mulatto) during a Pavlovian procedure with appetitive and aversive outcomes (liquid rewards and airpuffs directed at the face, respectively). We found that some dopamine neurons were excited by reward-predicting stimuli and inhibited by airpuff-predicting stimuli, as the value hypothesis predicts. However, a greater number of dopamine neurons were excited by both of these stimuli, inconsistent with the hypothesis. Some dopamine neurons were also excited by both rewards and airpuffs themselves, especially when they were unpredictable. Neurons excited by the airpuff-predicting stimuli were located more dorsolaterally in the substantia nigra pars com-pacta, whereas neurons inhibited by the stimuli were located more ventromedially, some in the ventral tegmental area. A similar anatomical difference was observed for their responses to actual airpuffs. These findings suggest that different groups of dopamine neurons convey motivational signals in distinct manners.
机译：中脑多巴胺神经元由奖励或预测奖励的感觉刺激激活。随着奖励价值的增加，这些兴奋反应也会增加5。这种反应特性导致了一个假设，即多巴胺神经元编码与价值相关的信号，并受到厌恶事件的抑制。在这里，我们证明这仅适用于多巴胺神经元的子集。我们记录了巴甫洛夫式手术过程中猴子的多巴胺神经元的活动，该过程具有开胃和厌恶的结果（分别将液体奖励和吹气对准面部）。我们发现，正如价值假设所预测的那样，一些多巴胺神经元被预测奖励的刺激所兴奋，而被气喘预测的刺激所抑制。但是，这两种刺激都刺激了更多的多巴胺神经元，这与假设不一致。一些多巴胺神经元也因奖赏和气嘴本身而兴奋，特别是当它们无法预测时。由气嘴预测的刺激激发的神经元位于黑质复合角膜的背外侧，而受刺激抑制的神经元位于腹侧，更靠近腹侧被盖区。观察到它们对实际气嘴的反应具有相似的解剖学差异。这些发现表明，不同组的多巴胺神经元以不同的方式传达激励信号。

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  • 来源
    《Nature》 |2009年第7248期|837-841|共5页
  • 作者

    Masayuki Matsumoto; Okihide Hikosaka;

  • 作者单位

    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-4435, USA;

    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-4435, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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