Cells reprogrammed for life

首页> 外文期刊>Nature >Cells reprogrammed for life

【24h】

Cells reprogrammed for life

机译：对细胞进行终身重编程

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Reproductive cells of multicellular organisms can achieve a form of immortality: germline cells - egg or sperm - generate the somatic cells of their offspring that die after a lifespan of growth and metabolism, but also produce germline cells that pass to the next generation. A study of a series of Caenorhabditis elegans mutants with increased longevity reveals that merely mortal soma cells can achieve increased longevity by activating gene expressionrnprograms controlled by the master regulator known as daf-16 in worms and FOXO in mammals, normally found only in 'immortal' germline cells.

机译：多细胞生物的生殖细胞可以达到永生的形式：种系细胞-卵或精子-产生其后代的体细胞，这些体细胞在生长和新陈代谢的寿命后死亡，但也产生可以传给下一代的种系细胞。对一系列寿命延长的秀丽隐杆线虫突变体的研究表明，仅致命的体细胞可以通过激活由蠕虫和哺乳动物FOXO的主要调节剂daf-16控制的基因表达程序来提高寿命，通常仅在“永生”中发现种系细胞。

著录项

来源
《Nature》 |2009年第25期|1030-1030|共1页
作者

展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Transgenic expression of Telomerase reverse transcriptase (Tert) improves cell proliferation of primary cells and enhances reprogramming efficiency into the induced pluripotent stem cell [J] . Hidema Shizu, Fukuda Tomokazu, Date Shiori, Bioscience, Biotechnology, and Biochemistry . 2016,第10期

机译：端粒酶逆转录酶（TERT）的转基因表达改善了原代细胞的细胞增殖，并增强了诱导多能干细胞的重编程效率
2. Proliferation of human hepatocellular carcinoma cells from surgically resected specimens under conditionally reprogrammed culture [J] . Wang Zhenglu, Bi Bowen, Song Hongli, Nature reviews Cancer . 2019,第6期

机译：在条件重新编程培养下，手术切除标本的人肝细胞癌细胞的激增
3. CD147 promotes reprogramming of glucose metabolism and cell proliferation in HCC cells by inhibiting the p53-dependent signaling pathway [J] . Qichao Huang, Jibin Li, Jinliang Xing, Journal of Hepatology: The Journal of the European Association for the Study of the Liver . 2014,第4期

机译：CD147通过抑制p53依赖性信号传导途径促进HCC细胞中葡萄糖代谢和细胞增殖的重编程
4. Differential adhesion strength as a molecular signature for rapid separation of partially reprogrammed cells from human stem cell reprogramming cultures [C] . Ankur Singh, Shalu Suri, Jamie M Chilton, Society for Biomaterials annual meeting and exposition . 2014

机译：差异粘附强度作为从人干细胞重编程培养物中快速分离部分重编程细胞的分子特征
5. Metabolic Reprogramming of T Cells to Optimize Adoptive T Cell Therapy [D] . Waller, Alexandra 2019

机译：T细胞的代谢重编程以优化过继性T细胞疗法
6. The glucose and lipid metabolism reprogramming is grade-dependent in clear cell renal cell carcinoma primary cultures and is targetable to modulate cell viability and proliferation [O] . Cristina Bianchi, Chiara Meregalli, Silvia Bombelli, 2017

机译：葡萄糖和脂质代谢的重编程在透明细胞肾细胞癌原代培养中是等级依赖性的并且可用于调节细胞活力和增殖
7. Proliferation of human hepatocellular carcinoma cells from surgically resected specimens under conditionally reprogrammed culture [O] . Zhenglu Wang, Bowen Bi, Hongli Song, 2019

机译：在条件重新编程培养下，手术切除标本的人肝细胞癌细胞的激增

Cells reprogrammed for life

摘要

著录项

相似文献

相关主题

期刊订阅