• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature >Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic
【24h】

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

机译：2009猪源H1N1甲型流感流行的起源和进化基因组学

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In March and early April 2009, a new swine-origin influenza A (H1N1) virus (S-OIV) emerged in Mexico and the United States. During the first few weeks of surveillance, the virus spread worldwide to 30 countries (as of May 11) by human-to-human transmission, causing the World Health Organization to raise its pandemic alert to level 5 of 6. This virus has the potential to develop into the first influenza pandemic of the twenty-first century. Here we use evolutionary analysis to estimate the time-scale of the origins and the early development of the S-OIV epidemic. We show that it was derived from several viruses circulating in swine, and that the initial transmission to humans occurred several months before recognition of the outbreak. A phylogenetic estimate of the gaps in genetic surveillance indicates a long period of unsampled ancestry before the S-OIV outbreak, suggesting that the reassortment of swine lineages may have occurred years before emergence in humans, and that the multiple genetic ancestry of S-OIV is not indicative of an artificial origin. Furthermore, the unsampled history of the epidemic means that the nature and location of the genetically closest swine viruses reveal little about the immediate origin of the epidemic, despite the fact that we included a panel of closely related and previously unpublished swine influenza isolates. Our results highlight the need for systematic surveillance of influenza in swine, and provide evidence that the mixing of new genetic elements in swine can result in the emergence of viruses with pandemic potential in humans.
机译：2009年3月至4月初，墨西哥和美国出现了一种新的源自猪的甲型H1N1流感病毒（S-OIV）。在监视的最初几周中，该病毒通过人对人的传播而传播到了30个国家（截至5月11日），导致世界卫生组织将大流行预警提高到6级的5级。发展成为二十一世纪的第一场流感大流行。在这里，我们使用进化分析来估计S-OIV流行的起源时间和早期发展。我们证明它是由猪中传播的几种病毒衍生而来的，并且最初的传播是在认识到这种暴发之前的几个月。系统监测缺口的系统发育估计表明，在S-OIV爆发之前有很长的未采样祖先，这表明猪谱系的重排可能已经在人类出现前数年发生，并且S-OIV的多重遗传是不表示人工来源。此外，未经抽样的流行病史意味着尽管我们包括了一组密切相关且以前未发表的猪流感分离株，但遗传上最接近的猪病毒的性质和位置几乎没有揭示流行的直接起源。我们的结果凸显了对猪流感进行系统监视的必要性，并提供了证据，证明猪中新遗传成分的混合可导致人类出现具有大流行潜力的病毒。

著录项

  • 来源
    《Nature》 |2009年第25期|1122-11251161-1162|共6页
  • 作者

    Gavin J. D. Smith; Dhanasekaran Vijaykrishna; Justin Bahl; Samantha J. Lycett; Michael Worobey; Oliver G. Pybus; Siu Kit Ma; Chung Lam Cheung; Jayna Raghwani; Samir Bhatt; J. S. Malik Peiris; Yi Guan; Andrew Rambaut;

  • 作者单位

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;

    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, Edinburgh EH9 3JT, UK.;

    Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85705, USA.;

    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;

    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, Edinburgh EH9 3JT, UK.;

    Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;

    State Key Laboratory of Emerging Infectious Diseases & Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China;

    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, King's Buildings, Edinburgh EH9 3JT, UK.;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号