Trimeric ion-channel design

Shai D. Silberberg; Kenton J. Swartz

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Trimeric ion-channel design

机译：三聚离子通道设计

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Ion channels are membrane-protein complexes that allow the passage of ions into and out of cells. One type of ion channel, the P2X receptor channel, is activated by extracellular ATP, the nucleotide more commonly known for providing cells with energy. Binding of ATP to the P2X receptor triggers opening of a transmembrane pore, allowing sodium, potassium and calcium ions to flow down their electrochemical gradients, changing membrane voltage or activating intracellular signalling cascades, mediating processes as diverse as pain perception and inflammation.

机译：离子通道是膜-蛋白质复合物，可以使离子进入细胞或从细胞中通过。一种类型的离子通道，P2X受体通道，被细胞外ATP激活，后者是众所周知的为细胞提供能量的核苷酸。 ATP与P2X受体的结合触发跨膜孔的开放，使钠，钾和钙离子沿其电化学梯度向下流动，改变膜电压或激活细胞内信号传导级联，介导疼痛感知和炎症等多种过程。

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来源
《Nature》 |2009年第7255期|580-581|共2页
作者
Shai D. Silberberg; Kenton J. Swartz;
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作者单位

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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3. A state-mutating genetic algorithm to design ion-channel models [J] . Vilas Menon, Nelson Spruston, William L. Kath Proceedings of the National Academy of Sciences of the United States of America . 2009,第39期

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Trimeric ion-channel design

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