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An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA

机译：由TERT和RMRP RNA形成的RNA依赖性RNA聚合酶

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摘要

Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage-hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICERD-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.
机译：端粒酶在人细胞中的组成型表达通过维持端粒稳态而防止了衰老和危机的发生。但是，越来越多的证据表明，人端粒酶逆转录酶催化亚基（TERT）与其延长端粒的能力无关，对细胞生理也有贡献。在这里，我们显示TERT与线粒体RNA加工内切核糖核酸酶（RMRP）的RNA成分相互作用，该基因在遗传多效性综合征软骨-头发发育不全中发生突变。人TERT和RMRP形成独特的核糖核蛋白复合物，具有RNA依赖性RNA聚合酶（RdRP）活性，并产生双链RNA，可在切丁机中加工成小干扰RNA（也称为DICERD依赖性）。哺乳动物RdRP，由TERT与RMRP组成。

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  • 来源
    《Nature》 |2009年第7261期|230-235|共6页
  • 作者

    Yoshiko Maida; Mami Yasukawa; Miho Furuuchi; Timo Lassmann; Richard Possemato; Naoko Okamoto; Vivi Kasim; Yoshihide Hayashizaki; William C. Hahn; Kenkichi Masutomi;

  • 作者单位

    Cancer Stem Cell Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;

    Cancer Stem Cell Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;

    Cancer Stem Cell Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;

    RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan;

    Department of Medical Oncology, Dana-Farber Cancer Institute and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA;

    Cancer Stem Cell Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;

    Cancer Stem Cell Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan;

    RIKEN Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan;

    Department of Medical Oncology, Dana-Farber Cancer Institute and Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School, 44 Binney Street, Boston, Massachusetts 02115, USA Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA;

    Cancer Stem Cell Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan PREST, Japan Science and Technology Agency, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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