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Chromosome crosstalk in three dimensions

机译:三维三维串扰

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摘要

The genome forms extensive and dynamic physical interactions with itself in the form of chromosome loops and bridges, thus exploring the three-dimensional space of the nucleus. It is now possible to examine these interactions at the molecular level, and we have gained glimpses of their functional implications. Chromosomal interactions can contribute to the silencing and activation of genes within the three-dimensional context of the nuclear architecture. Technical advances in detecting these interactions contribute to our understanding of the functional organization of the genome, as well as its adaptive plasticity in response to environmental changes during development and disease.
机译:基因组以染色体环和桥的形式与自身形成广泛而动态的物理相互作用,从而探索了核的三维空间。现在可以在分子水平上检查这些相互作用,并且我们已经了解了它们的功能含义。染色体相互作用可在核结构的三维环境内促进基因的沉默和激活。检测这些相互作用的技术进步有助于我们了解基因组的功能组织,以及其对发育和疾病期间环境变化的适应性可塑性。

著录项

  • 来源
    《Nature》 |2009年第7261期|212-217|共6页
  • 作者

    Anita Goendoer; Rolf Ohlsson;

  • 作者单位

    Department of Microbiology, Tumor and Cell Biology, Nobels vaeg 16, Box 280, Karolinska Institute, SE-171 77 Stockholm, Sweden;

    Department of Microbiology, Tumor and Cell Biology, Nobels vaeg 16, Box 280, Karolinska Institute, SE-171 77 Stockholm, Sweden;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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  • 正文语种 eng
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