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Designing materials to direct stem-cell fate

机译:设计材料指导干细胞命运

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摘要

Proper tissue function and regeneration rely on robust spatial and temporal control of biophysical and biochemical microenvironmental cues through mechanisms that remain poorly understood. Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful artificial microenvironments in which to study and instruct stem-cell fate both in culture and in vivo. Further synergism of cell biological and biomaterials technologies promises to have a profound impact on stem-cell biology and provide insights that will advance stem-cell-based clinical approaches to tissue regeneration.
机译:适当的组织功能和再生依赖于对生物物理和生化微环境线索的鲁棒的时空控制,其机制尚不清楚。生物材料正在迅速发展,以精确和接近生理的方式显示和传递干细胞调节信号,并成为强大的人工微环境,可在其中研究和指导培养和体内干细胞的命运。细胞生物学和生物材料技术的进一步协同作用有望对干细胞生物学产生深远影响,并提供见解,从而推动基于干细胞的临床方法实现组织再生。

著录项

  • 来源
    《Nature》 |2009年第7272期|433-441|共9页
  • 作者单位

    Institute of Bioengineering, Ecole Polytechnique Federate de Lausanne, CH-1015 Lausanne, Switzerland;

    Baxter Laboratory in 5tem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cells and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA;

    Baxter Laboratory in 5tem Cell Biology, Department of Microbiology and Immunology, Institute for Stem Cells and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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