The role of exercise and PGC1α in inflammation and chronic disease

Christoph Handschin; Bruce M. Spiegelman

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The role of exercise and PGC1α in inflammation and chronic disease

机译：运动和PGC1α在炎症和慢性疾病中的作用

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摘要

Inadequate physical activity is linked to many chronic diseases. But the mechanisms that tie muscle activity to health are unclear. The transcriptional coactivator PGC1α has recently been shown to regulate several exercise-associated aspects of muscle function. We propose that this protein controls muscle plasticity, suppresses a broad inflammatory response and mediates the beneficial effects of exercise.

机译：身体活动不足与许多慢性疾病有关。但是，将肌肉活动与健康联系起来的机制尚不清楚。转录共激活因子PGC1α最近被证明可以调节与肌肉功能有关的运动。我们建议该蛋白控制肌肉可塑性，抑制广泛的炎症反应，并介导运动的有益作用。

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《Nature》 |2008年第7203期|p.463-469|共7页
作者
Christoph Handschin; Bruce M. Spiegelman;
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作者单位

Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, CH-8057 Zurich, Switzerland;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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机译：运动对炎症和慢性病的作用
2. Age-associated chronic diseases require age-old medicine: role of chronic inflammation. [J] . Sahdeo Prasad, Bokyung Sung, Bharat B Aggarwal Preventive Medicine: An International Journal Devoted to Practice and Theory . 2012,第Suppla1期

机译：与年龄相关的慢性疾病需要使用古老的药物：慢性炎症的作用。
3. Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α [J] . Samuel K. Jensen, Nathan J. Michaels, Slava Ilyntskyy, Cell Reports . 2018,第12期

机译：多模式增强运动并具有枢轴作用的少突胶质PGC1α重新髓鞘形成。
4. Towards Self-management of Chronic Diseases in Smart Homes : Physical Exercise Monitoring for Chronic Obstruction Pulmonary Disease Patients [C] . José G. Teriús-Padrón, Georgios Kapidis, Sarah Fallmann, IEEE International Conference on Pervasive Computing and Communications Workshops . 2018

机译：走向智能家居中慢性病的自我管理：慢性阻塞性肺疾病患者的体育锻炼监测
5. Health-related quality of life, functional status, and exercise tolerance of adults with chronic obstructive pulmonary disease following three treatment situations: Exercise alone, exercise with a lecture series, and exercise with activity training. [D] . Migliore, Anna. 2003

机译：在以下三种治疗情况下，患有慢性阻塞性肺疾病的成年人的与健康相关的生活质量，功能状态和运动耐力：单独运动，进行系列演讲和进行运动训练。
6. The role of exercise and PGC1α in inflammation and chronic disease [O] . Christoph Handschin, Bruce M. Spiegelman -1

机译：运动和PGC1α在炎症和慢性疾病中的作用
7. The role of exercise and PGC1α in inflammation and chronic disease [O] . Handschin, C, Spiegelman, B M 2008

机译：运动和PGC1α在炎症和慢性疾病中的作用

The role of exercise and PGC1α in inflammation and chronic disease

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