Outcry at scale of inheritance project

Helen Pearson

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Outcry at scale of inheritance project

机译：继承项目规模大声疾呼

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The US National Institutes of Health (NIH) handed out the first payments in a multimillion-dollar project to explore epigenomics last month. But some researchers are voicing concerns about the scientific and economic justification for this latest 'big biology' venture. Epigenetics, described as "inheritance, but not as we know it", is now a blisteringly hot field. It is concerned with changes in gene expression that are typically inherited, but not caused by changes in gene sequence. In theory, epigenetic studies can help explain how the millions of cells in the human body can carry identical DNA but form completely different cell types, and perhaps why certain cells are susceptible to disease.

机译：美国国立卫生研究院（NIH）上个月在一项数百万美元的研究表观基因组学的项目中发放了第一笔款项。但是，一些研究人员对这种最新的“大生物学”冒险的科学和经济依据表示了担忧。表观遗传学被描述为“继承性，但不是我们所知道的”，现在是一个炙手可热的领域。它涉及通常是遗传的但不是由基因序列变化引起的基因表达变化。从理论上讲，表观遗传学研究可以帮助解释人体中数百万个细胞如何携带相同的DNA但形成完全不同的细胞类型，也许还解释了为什么某些细胞易患疾病。

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《Nature》 |2008年第7215期|p.845|共1页
作者
Helen Pearson;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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Outcry at scale of inheritance project

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