Trial and failure

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Trial and failure

机译：尝试与失败

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Last month saw the failure of a clinical trial of a cellulose sulphate vaginal gel as a protective measure against HIV infection (see page 12). The result was a disappointment for microbicide researchers, and a setback for millions of women in Africa and elsewhere who could benefit from such a product. The international trial, organized by CONRAD, a reproductive-health research group based in Virginia, ended when the gel in question was found not only to be ineffective, but actually to increase the risk of HIV infection.

机译：上个月，硫酸纤维素阴道凝胶作为抗HIV感染的保护措施的临床试验失败了（请参阅第12页）。结果使杀微生物剂研究人员感到失望，并使非洲和其他地方数百万可以从这种产品中受益的妇女遭受挫折。由总部位于弗吉尼亚州的生殖健康研究小组CONRAD组织的国际试验结束时，发现所研究的凝胶不仅无效，而且实际上增加了HIV感染的风险。

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《Nature》 |2007年第7131期|p.1|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure (CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza Cardiaca-Heart Failure (GISSI-HF) Trials [J] . Abdul-Rahim Azmil H., Perez Ana-Cristina, Fulton Rachael L., Circulation: An Official Journal of the American Heart Association . 2015,第17期

机译：慢性心力衰竭患者的卒中风险，如果未进行房颤的多中心试验性心力衰竭（CORONA）和控制性瑞舒伐他汀治疗心律失常的心律失常分析，则需进行心房颤动的风险
2. Letter by Lin et al Regarding Article, " Risk of Stroke in Chronic Heart Failure Patients Without Atrial Fibrillation: Analysis of the Controlled Rosuvastatin in Multinational Trial Heart Failure ( CORONA) and the Gruppo Italiano per lo Studio della Sopravvivenza nell'Insufficienza CardiacaHeart Failure ( GISSI- HF) Trials." [J] . Lin Gen-Min, Hung Yuan, Li Yi-Hwei Circulation: An Official Journal of the American Heart Association . 2015,第22期

机译：林等人关于文章的信，“慢性心力衰竭患者中风的风险没有心房颤动：分析跨国试验心力衰竭（电晕）和Gruppo Italiano的受控罗萨替腊替腊肠，每Lo Studio Della Sopravvivenza Nell'insufficienza Cardiacaheart失败（Gissi - HF）试验。“
3. Racial differences in response to therapy for heart failure: analysis of the vasodilator-heart failure trials. Vasodilator-Heart Failure Trial Study Group. [J] . Carson P, Ziesche S, Johnson G, Journal of cardiac failure . 1999,第3期

机译：应对心力衰竭的种族差异：血管扩张剂-心力衰竭试验的分析。血管扩张剂-心力衰竭试验研究组。
4. Field investigations of perceived PCV2 vaccine failures and experimental challenge trials that support transitioning to a PCV2b-based vaccine [C] . Tanja Opriessnig, Kevin ONeill, Priscilla Gerber, Annual^Meeting of the American Association^of^Swine^Veterinarians. . 2013

机译：对PCV2疫苗失败和实验挑战试验的现场调查，其支持转换到基于PCV2B的疫苗
5. Factors associated with adherence in heart failure. A secondary analysis of a large clinical trial: Candesartan in Heart failure -Assessment of Reduction in Mortality and Morbidity (CHARM) [D] . Granger, Bradi B. 2004

机译：与心力衰竭依从性相关的因素。大型临床试验的次要分析：坎地沙坦治疗心力衰竭-死亡率和发病率降低的评估（CHARM）
6. A randomised controlled trial of a personalised lifestyle coaching application in modifying periconceptional behaviours in women suffering from reproductive failures (iPLAN trial) [O] . Ka Ying Bonnie Ng, Susan Wellstead, Ying Cheong, 2018

机译：个性化生活方式指导应用程序在改变患有生殖衰竭的女性的经膜行为方面的随机对照试验（iPLAN试验）
7. The DANish randomized, double-blind, placebo controlled trial in patients with chronic HEART failure (DANHEART): A 2 × 2 factorial trial of hydralazine-isosorbide dinitrate in patients with chronic heart failure (H-HeFT) and metformin in patients with chronic heart failure and diabetes or prediabetes (Met-HeFT) [O] . Henrik Wiggers, Lars Køber, Gunnar Gislason, 2021

机译：丹麦随机，双盲，安慰剂对照试验，慢性心力衰竭患者（丹霍特）：慢性心力衰竭（H-HEFET）和慢性心脏患者患者含氢吡嗪 - 异山梨醇的2×2因子试验失败和糖尿病或前奶油蛋白（梅特 - HEFT）

Trial and failure

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