Aneuploidy and cancer

David Pellman

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Aneuploidy and cancer

机译：非整倍体与癌症

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Aneuploidy is the condition in which a cell has extra or missing chromosomes, and is often associated with tumours. But whether it is a cause or a consequence of cancer remains a vexed question. Aneuploid cancers are like Tolstoy's unhappy families: each aneuploid cancer has its own particular abnormal chromosome content, and thus its own abnormal characteristics. This variability has long frustrated biologists trying to establish whether aneuploidy is a cause or a consequence of malignant transformation. Two papers in Cancer Cell advance the argument for 'cause', but with qualifications.

机译：非整倍性是细胞具有多余或缺失的染色体的病状，通常与肿瘤有关。但是，究竟是癌症的原因还是后果仍然是一个令人困扰的问题。非整倍体癌症就像托尔斯泰的不幸家庭一样：每种非整倍体癌症都有其特定的异常染色体含量，因此具有其异常特征。长期以来，这种可变性使生物学家感到沮丧，他们试图确定非整倍性是恶性转化的原因还是后果。《癌细胞》（Cancer Cell）上的两篇论文提出了“原因”（cause）的论点，但具有限定性。

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来源
《Nature》 |2007年第7131期|p.38-39|共2页
作者
David Pellman;
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作者单位

Dana-Farber Cancer Institute, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Do oestrogens induce chromosome specific aneuploidy in vitro, similar to the pattern of aneuploidy seen in breast cancer? [J] . Quick EL, Parry EM, Parry JM Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2008,第1a2期

机译：雌激素是否在体外诱导染色体特异性非整倍性，类似于在乳腺癌中看到的非整倍性模式？
2. Glutathione reductase ( GSR ) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization [J] . Mohamed Baity, Wayne L Hofstetter, Reza J Mehran, American Journal of Cancer Research . 2019,第6期

机译：荧光原位杂交检测的原发性肺癌中谷胱甘肽还原酶（GSR）基因缺失和染色体8室内倍性
3. Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin [J] . Pallai Rajash, Bhaskar Aishwarya, Barnett-Bernodat Natalie, Tumour biology : . 2015,第8期

机译：蛋白磷酸酶2A的癌性抑制剂通过与守护甜素的结合促进前列腺癌细胞中的早熟染色体分离和非整倍性
4. Mechanism of Carcinogenesis by Polycyclic Aromatic Hydrocarbons: Aneuploidy precedes malignant transformation and occurs in all cancers [C] . Peter Duesberg, Ruhong Li, Charlotte Rausch, NATO advanced research workshop on technological and medical implications of metabolic control analysis . 2000

机译：多环芳烃致癌机制：非倍差之前的恶性转化并发生在所有癌症中
5. Studies of human aneuploidy: Assessment of gametic aneuploidy and analysis of the etiology of mosaic Down syndrome. [D] . Gursoy, Nurcan. 2001

机译：人类非整倍性的研究：配子非整倍性的评估和镶嵌唐氏综合症的病因分析。
6. Aneuploidy vs. gene mutation hypothesis of cancer: Recent study claims mutation but is found to support aneuploidy [O] . Ruhong Li, Arvind Sonik, Reinhard Stindl, 2000

机译：癌症的非整倍性与基因突变假说：最新研究声称突变但被发现支持非整倍性
7. Aneuploidy and Epithelial Cancers: The Impact of Aneuploidy on the Genesis, Progression and Prognosis of Colorectal and Breast Carcinomas [O] . Jens K., Gert Auer, Madhvi Upender, 2012

机译：一种非倍性和上皮癌：非整倍性对结直肠癌和乳腺癌的成因，进展和预后的影响

Aneuploidy and cancer

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