C. difficile toxins made toxic

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C. difficile toxins made toxic

机译：艰难梭菌毒素产生毒性

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Clostridium difficile is a major cause of hospital-acquired infection. It is found in the large intestine in some healthy adults and it is attrition among 'good' intestinal bacteria during antibiotic therapy that creates the conditions in which C. difficile toxins cause diarrhoea and colitis. A new study shows that cleavage of all large clostridial cytotoxins is an autocatalytic process — that is, the toxin activates itself— induced by host inositol phosphate cofactors.

机译：艰难梭菌是医院获得性感染的主要原因。它在一些健康的成年人的大肠中被发现，在抗生素治疗过程中“好”肠细菌之间的磨损，导致艰难梭菌毒素引起腹泻和结肠炎。一项新研究表明，裂解所有大型梭菌细胞毒素是一种自动催化过程，也就是说，该毒素会自我活化，这是由宿主肌醇磷酸酯辅因子诱导的。

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《Nature》 |2007年第7134期|p.xvii|共1页
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Evaluation of the C. DIFFICILE TOXIN A/B IITM, C. DIFF CHEK-60TM, and PREMIER TOXIN A&BTM with the cytotoxin assay for the detection of Clostridium difficile GDH antigen and toxins A and B in feces [J] . W.Greene International journal of infectious diseases : . 2010,第Supplementa1期

机译：使用细胞毒素测定法评估难辨梭菌毒素A / B IITM，难辨梭菌CHEK-60TM和PREMIER毒素A＆BTM的能力，以检测艰难梭菌GDH抗原以及粪便中的毒素A和B
2. Evaluation of 3 automated real-time PCR (Xpert C. difficile assay, BD MAX Cdiff, and IMDx C. difficile for Abbott m2000 assay) for detecting Clostridium difficile toxin gene compared to toxigenic culture in stool specimens [J] . Yoo Jaeeun, Lee Hyeyoung, Park Kang Gyun, Diagnostic microbiology and infectious disease . 2015,第1期

机译：评估3种自动实时PCR（用于雅培m2000检测的Xpert艰难梭菌测定，BD MAX Cdiff和IMDx艰难梭菌）与粪便标本中的产毒培养相比检测艰难梭菌毒素基因
3. Evaluation of LIAISON? C. difficile glutamate dehydrogenase and LIAISON? C. difficile toxin A and B in Copan FecalSwabTM samples in a three-step algorithm for the diagnosis of Clostridium difficile infection [J] . Massimo Oggioni, Alessandra Bielli, Alice Nava, Microbiologia Medica . 2015,第1期

机译：评价LIAISON？艰难梭菌谷氨酸脱氢酶和LIAISON？采用三步法诊断Copan FecalSwabTM样品中的艰难梭菌毒素A和B，用于诊断艰难梭菌感染
4. EXPERIMENTAL MODEL OF DUODENITIS PROXIMAL-JEJUNITIS IN HORSES INOCULATED WITH CLOSTRIDIUM DIFFICILE TOXINS [C] . Luis Arroyo, Marcio Costa, Bruce Guest, Conference of the American^College^of^Veterinary^Internal^Medicine . 2016

机译：用梭菌梭菌毒素接种的马匹腹膜炎 - 赤羽炎的实验模型
5. Development of peptide inhibitors targeting Clostridium difficile toxins A/B and characterizing the regulatory role of a putative negative regulator TcdC in Clostridium difficile toxin gene expression. [D] . Abdeen, Sanofar J. 2013

机译：靶向艰难梭菌毒素A / B的肽抑制剂的开发以及表征推定的负调节剂TcdC在艰难梭菌毒素基因表达中的调节作用。
6. Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins. [O] . C P Kelly, C Pothoulakis, F Vavva, 1996

机译：抗艰难梭菌牛免疫球蛋白浓缩物可抑制艰难梭菌毒素的细胞毒性和肠毒性。
7. Anti-Clostridium difficile bovine immunoglobulin concentrate inhibits cytotoxicity and enterotoxicity of C. difficile toxins [O] . C P Kelly, C Pothoulakis, F Vavva, 1996

机译：抗梭菌差异牛免疫球蛋白浓缩物抑制C.艰难梭菌毒素的细胞毒性和肠毒性
8. Evaluation and Research on Antimicrobial Stewardship's Effect on Clostridium difficile (ERASE C. difficile) Project. Toolkit for Reduction of Clostridium difficile through Antimicrobial Stewardship. [R] . 2012

机译：抗菌药物管理对艰难梭菌（ERasE C. difficile）项目影响的评价与研究。通过抗菌药物管理减少艰难梭菌的工具包。

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C. difficile toxins made toxic

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